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  1. Research

    Caffeine modulates glucocorticoid-induced expression of CTGF in lung epithelial cells and fibroblasts

    Although caffeine and glucocorticoids are frequently used to treat chronic lung disease in preterm neonates, potential interactions are largely unknown. While anti-inflammatory effects of glucocorticoids are w...

    Markus Fehrholz, Kirsten Glaser, Christian P. Speer, Silvia Seidenspinner, Barbara Ottensmeier and Steffen Kunzmann

    Respiratory Research 2017 18:51

    Published on: 23 March 2017

  2. Research

    Cigarette smoke challenges bone marrow mesenchymal stem cell capacities in guinea pig

    Cigarette smoke (CS) is associated with lower numbers of circulating stem cells and might severely affect their mobilization, trafficking and homing. Our study was designed to demonstrate in an animal model of...

    Olga Tura-Ceide, Borja Lobo, Tanja Paul, Raquel Puig-Pey, Núria Coll-Bonfill, Jéssica García-Lucio, Valérie Smolders, Isabel Blanco, Joan A. Barberà and Víctor I. Peinado

    Respiratory Research 2017 18:50

    Published on: 23 March 2017

  3. Research

    Interaction of CD14 haplotypes and soluble CD14 on pulmonary function in agricultural workers

    Agricultural environments are contaminated with organic dusts containing bacterial components. Chronic inhalation of organic dusts is implicated in respiratory diseases. CD14 is a critical receptor for gram-ne...

    Tricia D. LeVan, Lynette M. Smith, Art J. Heires, Ted R. Mikuls, Jane L. Meza, Lisa A. Weissenburger-Moser and Debra J. Romberger

    Respiratory Research 2017 18:49

    Published on: 16 March 2017

  4. Letter to the Editor

    Increased IL-17RA and IL-17RC in End-Stage COPD and the Contribution to Mast Cell Secretion of FGF-2 and VEGF

    Mast cells are accumulated in advanced chronic obstructive pulmonary disease (COPD), and interleukin (IL)-17 signaling plays a role in disease progression. The expression, localization and functional relevance...

    Abraham B. Roos, Michiko Mori, Harpreet K. Gura, Axel Lorentz, Leif Bjermer, Hans Jürgen Hoffmann, Jonas S. Erjefält and Martin R. Stampfli

    Respiratory Research 2017 18:48

    Published on: 15 March 2017

  5. Letter to the Editor

    Chronic hypoxia aggravates monocrotaline-induced pulmonary arterial hypertension: a rodent relevant model to the human severe form of the disease

    Pulmonary arterial hypertension (PAH) is a severe form of pulmonary hypertension that combines multiple alterations of pulmonary arteries, including, in particular, thrombotic and plexiform lesions. Multiple-p...

    Florence Coste, Christelle Guibert, Julie Magat, Emma Abell, Fanny Vaillant, Mathilde Dubois, Arnaud Courtois, Philippe Diolez, Bruno Quesson, Roger Marthan, Jean-Pierre Savineau, Bernard Muller and Véronique Freund-Michel

    Respiratory Research 2017 18:47

    Published on: 14 March 2017

  6. Research

    Combination of glycopyrronium and indacaterol inhibits carbachol-induced ERK5 signal in fibrotic processes

    Airway fibrosis is one of the pathological features of chronic obstructive pulmonary disease (COPD), and recent studies revealed that acetylcholine plays an important role in the development of airway remodeli...

    Yukiko Namba, Shinsaku Togo, Miniwan Tulafu, Kotaro Kadoya, Kumi Yoneda Nagahama, Hikari Taka, Naoko Kaga, Akira Orimo, Xiangde Liu and Kazuhisa Takahashi

    Respiratory Research 2017 18:46

    Published on: 11 March 2017

  7. Research

    Densitometric and local histogram based analysis of computed tomography images in patients with idiopathic pulmonary fibrosis

    Prior studies of clinical prognostication in idiopathic pulmonary fibrosis (IPF) using computed tomography (CT) have often used subjective analyses or have evaluated quantitative measures in isolation. This st...

    Samuel Y. Ash, Rola Harmouche, Diego Lassala Lopez Vallejo, Julian A. Villalba, Kris Ostridge, River Gunville, Carolyn E. Come, Jorge Onieva Onieva, James C. Ross, Gary M. Hunninghake, Souheil Y. El-Chemaly, Tracy J. Doyle, Pietro Nardelli, Gonzalo V. Sanchez-Ferrero, Hilary J. Goldberg, Ivan O. Rosas…

    Respiratory Research 2017 18:45

    Published on: 7 March 2017

  8. Letter to the Editor

    The relationship between the Leicester cough questionnaire, eosinophilic airway inflammation and asthma patient related outcomes in severe adult asthma

    Severe asthma is characterised by a variety of symptoms, which include chronic cough, however the mechanisms responsible for cough reflex hypersensitivity in asthma remain poorly elucidated. Current asthma pat...

    Sushiladevi Natarajan, Robert C. Free, Peter Bradding, Lorcan McGarvey and Salman Siddiqui

    Respiratory Research 2017 18:44

    Published on: 4 March 2017

  9. Research

    Low tissue levels of miR-125b predict malignancy in solitary fibrous tumors of the pleura

    Solitary fibrous tumors of the pleura (SFTP) are rare neoplasia of the chest. A subset of SFTP follows a malignant course, sometimes several years after complete resection. Traditional scoring systems based on...

    Matthias Brock, Selma Hottinger, Matthias Diebold, Alex Soltermann, Wolfram Jochum, Malcolm Kohler, Lars C. Huber and Daniel P. Franzen

    Respiratory Research 2017 18:43

    Published on: 2 March 2017

  10. Research

    GDF-15 plasma levels in chronic obstructive pulmonary disease are associated with subclinical coronary artery disease

    Growth differentiation factor-15 (GDF-15), a cytokine associated with cardiovascular mortality, increases during chronic obstructive pulmonary disease (COPD) exacerbations, but any role in stable COPD is unkno...

    Carlos H. Martinez, Christine M. Freeman, Joshua D. Nelson, Susan Murray, Xin Wang, Matthew J. Budoff, Mark T. Dransfield, John E. Hokanson, Ella A. Kazerooni, Gregory L. Kinney, Elizabeth A. Regan, J. Michael Wells, Fernando J. Martinez, MeiLan K. Han and Jeffrey L. Curtis

    Respiratory Research 2017 18:42

    Published on: 28 February 2017

  11. Research

    Dual polarization of human alveolar macrophages progressively increases with smoking and COPD severity

    It is known that tissue macrophages derive not only from blood monocytes but also from yolk sac or fetal liver, and the tissue of residence guides their function. When isolated, they lose tissue specific signa...

    Erica Bazzan, Graziella Turato, Mariaenrica Tinè, Claudia M. Radu, Elisabetta Balestro, Chiara Rigobello, Davide Biondini, Marco Schiavon, Francesca Lunardi, Simonetta Baraldo, Federico Rea, Paolo Simioni, Fiorella Calabrese, Marina Saetta and Manuel G. Cosio

    Respiratory Research 2017 18:40

    Published on: 23 February 2017

  12. Research

    Cluster analysis of sputum cytokine-high profiles reveals diversity in T(h)2-high asthma patients

    Asthma is characterized by a heterogeneous inflammatory profile and can be subdivided into T(h)2-high and T(h)2-low airway inflammation. Profiling of a broader panel of airway cytokines in large unselected pat...

    Sven F. Seys, Hans Scheers, Paul Van den Brande, Gudrun Marijsse, Ellen Dilissen, Annelies Van Den Bergh, Pieter C. Goeminne, Peter W Hellings, Jan L. Ceuppens, Lieven J Dupont and Dominique M. A. Bullens

    Respiratory Research 2017 18:39

    Published on: 23 February 2017

  13. Research

    Dibutyryl-cAMP attenuates pulmonary fibrosis by blocking myofibroblast differentiation via PKA/CREB/CBP signaling in rats with silicosis

    Myofibroblasts play a major role in the synthesis of extracellular matrix (ECM) and the stimulation of these cells is thought to play an important role in the development of silicosis. The present study was un...

    Yan Liu, Hong Xu, Yucong Geng, Dingjie Xu, Lijuan Zhang, Yi Yang, Zhongqiu Wei, Bonan Zhang, Shifeng Li, Xuemin Gao, Ruimin Wang, Xianghong Zhang, Darrell Brann and Fang Yang

    Respiratory Research 2017 18:38

    Published on: 21 February 2017

  14. Research

    Clarithromycin attenuates IL-13–induced periostin production in human lung fibroblasts

    Periostin is a biomarker indicating the presence of type 2 inflammation and submucosal fibrosis; serum periostin levels have been associated with asthma severity. Macrolides have immunomodulatory effects and a...

    Kosaku Komiya, Shoichiro Ohta, Kazuhiko Arima, Masahiro Ogawa, Shoichi Suzuki, Yasutaka Mitamura, Satoshi Nunomura, Yasuhiro Nanri, Tomohito Yoshihara, Atsushi Kawaguchi, Jun-ichi Kadota, Bruce K. Rubin and Kenji Izuhara

    Respiratory Research 2017 18:37

    Published on: 20 February 2017

  15. Research

    Malondialdehyde-acetaldehyde (MAA) adducted surfactant protein induced lung inflammation is mediated through scavenger receptor a (SR-A1)

    Co-exposure to cigarette smoke and alcohol leads to the generation of high concentrations of acetaldehyde and malondialdehyde in the lung. These aldehydes being highly electrophilic in nature react with biolog...

    Muna Sapkota, Jane M. DeVasure, Kusum K. Kharbanda and Todd A. Wyatt

    Respiratory Research 2017 18:36

    Published on: 13 February 2017

  16. Letter to the Editor

    Acute effects of nicotine-free and flavour-free electronic cigarette use on lung functions in healthy and asthmatic individuals

    We designed a crossover and placebo-controlled trial to investigate the impact of a 1-h acute vaping session of nicotine-free and flavour-free e-liquid on the pulmonary functions and respiratory mechanics of h...

    Marie-Ève Boulay, Cyndi Henry, Ynuk Bossé, Louis-Philippe Boulet and Mathieu C. Morissette

    Respiratory Research 2017 18:33

    Published on: 10 February 2017

  17. Research

    Collaboration between specialties for respiratory allergies in the International Classification of Diseases (ICD)-11

    The International Classification of Diseases (ICD) has been grouping the allergic and hypersensitivity disorders involving the respiratory tract under topographic distribution, regardless of the underlying mec...

    Luciana Kase Tanno, Moises Calderon, Jeffrey F. Linzer, Robert J.G. Chalmers and Pascal Demoly

    Respiratory Research 2017 18:34

    Published on: 10 February 2017

  18. Research

    Imatinib relaxes the pulmonary venous bed of guinea pigs

    Recently, the IMPRES study revealed that systemic imatinib improves exercise capacity in patients with advanced pulmonary arterial hypertension. Imatinib blocks the tyrosine kinase activity of the platelet-der...

    Nina A. Maihöfer, Said Suleiman, Daniela Dreymüller, Paul W. Manley, Rolf Rossaint, Stefan Uhlig, Christian Martin and Annette D. Rieg

    Respiratory Research 2017 18:32

    Published on: 8 February 2017

  19. Research

    The role of serum procalcitonin in establishing the diagnosis and prognosis of pleural infection

    Bacterial pleural infection requires prompt identification to enable appropriate investigation and treatment. In contrast to commonly used biomarkers such as C-reactive protein (CRP) and white cell count (WCC)...

    Giles Dixon, Adriana Lama-Lopez, Oliver J. Bintcliffe, Anna J. Morley, Clare E. Hooper and Nick A. Maskell

    Respiratory Research 2017 18:30

    Published on: 3 February 2017

  20. Letter to the Editor

    Changes in the respiratory microbiome during acute exacerbations of idiopathic pulmonary fibrosis

    Acute exacerbations of idiopathic pulmonary fibrosis (AE-IPF) have been defined as events of clinically significant respiratory deterioration with an unidentifiable cause. They carry a significant mortality an...

    Philip L. Molyneaux, Michael J Cox, Athol U. Wells, Ho Cheol Kim, Wonjun Ji, William O. C. Cookson, Miriam F. Moffatt, Dong Soon Kim and Toby M. Maher

    Respiratory Research 2017 18:29

    Published on: 1 February 2017

  21. Research

    High throughput 16SrRNA gene sequencing reveals the correlation between Propionibacterium acnes and sarcoidosis

    This study aims to use high throughput 16SrRNA gene sequencing to examine the bacterial profile of lymph node biopsy samples of patients with sarcoidosis and to further verify the association between Propionib...

    Meng-Meng Zhao, Shan-Shan Du, Qiu-Hong Li, Tao Chen, Hui Qiu, Qin Wu, Shan-Shan Chen, Ying Zhou, Yuan Zhang, Yang Hu, Yi-Liang Su, Li Shen, Fen Zhang, Dong Weng and Hui-Ping Li

    Respiratory Research 2017 18:28

    Published on: 1 February 2017

  22. Research

    Diesel exhaust alters the response of cultured primary bronchial epithelial cells from patients with chronic obstructive pulmonary disease (COPD) to non-typeable Haemophilus influenzae

    Exacerbations constitute a major cause of morbidity and mortality in patients suffering from chronic obstructive pulmonary disease (COPD). Both bacterial infections, such as those with non-typeable Haemophilus in...

    Maria C. Zarcone, Annemarie van Schadewijk, Evert Duistermaat, Pieter S. Hiemstra and Ingeborg M. Kooter

    Respiratory Research 2017 18:27

    Published on: 28 January 2017

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