Fig. 8From: Downregulation of HMGCS2 mediated AECIIs lipid metabolic alteration promotes pulmonary fibrosis by activating fibroblastsHMGCS2 alleviates lung fibrosis by regulating AECIIs lipid metabolism. Decreased expression of HMGCS2 in AECIIs leads to lipid accumulation. Lipid such as LysoPC determined in our study released by injured AECIIs could activate surrounding lung fibroblast therefore facilitating fibrotic progressionBack to article page