Fig. 3From: Downregulation of HMGCS2 mediated AECIIs lipid metabolic alteration promotes pulmonary fibrosis by activating fibroblastsHMGCS2 was down regulated in IPF patients and associated with lung function. A, HMGCS2 was significantly down regulated in IPF patients (N = 254) compared with healthy individuals (N = 108) (GES47460). B, The expression pattern of HMGCS2 was further confirmed in IPF lung sections (Normal looking alveolar area VS dense fibrotic region), scale bar = 20 μm. C, HMGCS2 expression was positively correlated with lung function in IPF cohort (GES47460) (DLCO, R = 0.44, P < 0.01), forced expiratory volume (FEV, R = 0.23, P < 0.01), and forced vital capacity (FVC, R = 0.30, P < 0.01), Data are expressed as mean ± SD, *: p < 0.05; **: p < 0.01Back to article page