Table 2 Unbound fraction of compounds in whole blood
From: PI3Kγδ inhibition suppresses key disease features in a rat model of asthma
Compound | Human ppb (fu, %) | Human plasma fu | Fu’ |
|---|---|---|---|
PI3Kγδ - AZD8154 | 0.63 | 0.0063 | 0.060 |
PI3Kδ - GSK2269557 | 2.1 | 0.021 | 0.177 |
PI3Kγ - AZD3458 | 15 | 0.15 | 0.638 |