Table 1 Unbound fraction of compounds in whole blood
From: PI3Kγδ inhibition suppresses key disease features in a rat model of asthma
Compound | Rat ppb (fu, %) | Rat plasma fu | Rat B/P ratio | Rat fub | DF | fu’ |
|---|---|---|---|---|---|---|
PI3Kγδ - AZD8154 | 1.5 | 0.015 | 0.82 | 0.018 | 1.05 | 0.0192 |
PI3Kδ - GSK2269557 | 4.4 | 0.044 | 0.88 | 0.050 | 1.05 | 0.0524 |
PI3Kγ - AZD3458 | 15 | 0.15 | 0.75 | 0.200 | 1.05 | 0.2079 |