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Fig. 5 | Respiratory Research

Fig. 5

From: Decreased serpin C1 in extracellular vesicles predicts response to methotrexate treatment in patients with pulmonary sarcoidosis

Fig. 5

Concentrations of EV proteins in patients with sarcoidosis treated with methotrexate of the replication cohort (n = 82), measured in different EV fractions as well as in whole serum. Figure (a) represents concentrations of Serpin C1 in the LDL fraction; figure (b) concentrations of CD14 in the LDL fraction, and figure (c) concentrations of cystatin C in the HDL fraction in non-responders and responders to treatment with methotrexate. Serpin C1 concentrations were significantly higher in non-responders than in responders (p = 0.032). Black filled squares represent non-responders (NR) and gray open squares represent responders (R) to treatment with methotrexate. *p < 0.05

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