Characteristics | Control subjects (n = 10) | PAH patients (n = 30) | P value |
---|---|---|---|
Age (years), mean ± sd | 51.6 ± 6.1319 | 47.633 ± 15.865 | 0.262 |
Sex, n (%) | Â | Â | 0.690 |
Female | 6 (60%) | 22 (73.33%) | Â |
Male | 4 (40%) | 8 (26.67%) | Â |
HR (beats/min), median (IQR) | 70 (66, 78.5) | 69 (65.25, 75.25) | 0.790 |
BMI (kg/m2), median (IQR) | 21.955 (21.332, 23.125) | 22.02 (20.755, 24.703) | 0.938 |
NYHA class, n (%) | Â | Â | N/A |
I - II | N/A | 7 (23.33%) | Â |
III - IV | N/A | 23 (76.67%) | Â |
6MWD (m), median (IQR) | Â | 175 (116.25, 242.5) | N/A |
Hemodynamic | Â | Â | Â |
mPAP (mmHg), median (IQR) | N/A | 67 (48.5, 73) | N/A |
PCWP (mmHg), median (IQR) | N/A | 9 (7, 11.75) | N/A |
PVR (wood units), mean ± sd | N/A | 9.6287 ± 5.605 | N/A |
CI (L/min/m2), median (IQR) | N/A | 2.4 (2.2, 2.875) | N/A |
Biochemical markers | Â | Â | Â |
NT-proBNP (pg/mL), median (IQR) | 38 (33.25, 55.25) | 1160 (491, 2377.5) | < 0.001 |
Troponin I (ng/mL), median (IQR) | 0.018 (0.01525, 0.0205) | 0.0165 (0.007275, 0.0215) | 0.435 |
D-dimer (ug/L), median (IQR) | 347 (317.25, 461.75) | 583 (262, 895.25) | 0.246 |
Total bilirubin (µmol/L), median (IQR) | 13.65 (10.8, 15.425) | 11.85 (9.275, 17.275) | 0.864 |
ALT (U/L), median (IQR) | 18 (12.75, 22.5) | 11 (9, 22) | 0.324 |
AST (U/L), median (IQR) | 25.5 (21.25, 26.75) | 20 (16, 23) | 0.054 |
Triglyceride (mmol/L), median (IQR) | 1.485 (0.965, 1.7475) | 1.155 (0.8625, 1.47) | 0.281 |
High-density lipoprotein (mmol/L), mean ± sd | 2.512 ± 1.0959 | 1.284 ± 0.46964 | 0.006 |
Low-density lipoprotein (mmol/L), mean ± sd | 1.467 ± 0.52915 | 1.7763 ± 0.43843 | 0.074 |
BUN (mmol/L), median (IQR) | 4.65 (3.525, 5.55) | 4.95 (3.725, 5.775) | 0.790 |
Cr (umol/L), median (IQR) | 61 (50.5, 77) | 59.5 (48.5, 74) | 0.650 |
UA (umol/L), mean ± sd | 214 ± 57.329 | 438.87 ± 137.41 | < 0.001 |
Echocardiography | Â | Â | Â |
LVEF (%), median (IQR) | 77.5 (75.25, 79.5) | 71 (65.25, 77.75) | 0.063 |
Right atrial diameters (mm), mean ± sd | 34.4 ± 4.4272 | 33.9 ± 3.0212 | 0.690 |
Right ventricular diameters (mm), median (IQR) | 31.5 (30, 32) | 36 (34.25, 38.75) | < 0.001 |
Left atrial diameters (mm), mean ± sd | 31.6 ± 3.2387 | 29.967 ± 3.3578 | 0.187 |
Left-ventricular end-diastolic diameter (mm), mean ± sd | 36.8 ± 2.044 | 35.733 ± 3.8141 | 0.406 |
Pulmonary artery diameter (mm), mean ± sd | 28.2 ± 3.2592 | 29.345 ± 2.3188 | 0.234 |
Mitral orifice flow velocity (m/s), mean ± sd | 0.83 ± 0.19465 | 0.77433 ± 0.23485 | 0.504 |
Aortic orifice velocity (m/s), median (IQR) | 1.45 (1.1875, 1.575) | 1.4 (1.2, 1.6) | 0.962 |
Pulmonary valvular orifice velocity(m/s), mean ± sd | 1.2 ± 0.27889 | 1.145 ± 0.21043 | 0.514 |