Fig. 3

A FZD1,2,5,7,8 targeted WNT mimetic (R2M3-26) is effective in the acute bleomycin model. (A) Survival curves by treatment. The treatment legend applies to all graphs in the figure: Saline (uninjured), Anti-GFP (10 mpk), R2M3-26 (10 mpk), RSPO2 (1 mpk), RSPO2 (4.6 mpk), R2M3-26 (1 mpk) + RSPO2 (0.3 mpk). (B) Percentage bodyweight relative to day 0 for all groups. (C-E) Histopathology assessments. The Severity Score is a composite of multiple histopathology metrics presented in Supplementary Table 1. (F) ACTA2 positive area as a percentage of tissue area. (C-F) Error bars represent SEM; * p value < 0.05, ** < 0.01, *** < 0.001, **** < 0.0001. (G) Representative images of Masson’s trichrome staining in which collagen is blue; scale bar = 1 mm. (H) Example IF images of ACTA2 and SFTPC; scale bar = 200 μm