Table 1 Basic characteristics of the subjects
From: Neopterin in patients with COPD, asthma, and ACO: association with endothelial and lung functions
Asthma (n = 20) | ACO (n = 20) | COPD (n = 20) | HC (n = 17) | P value | |
|---|---|---|---|---|---|
Age | 57.2 ± 9.3 | 56.8 ± 9.0 | 58.9 ± 6.6 | 52.5 ± 6.9 | 0.113 |
Male, n (%) | 12 ((60) | 16 (80) | 20 (100) | 12 (71) | 0.019 |
Height, m | 1.6 ± 0.1 | 1.7 ± 0.1 | 1.7 ± 0.1 | 1.6 ± 0.1 | 0.121 |
Weight, kg | 63.8 ± 9.0 | 65.1 ± 11.8 | 58.6 ± 8.8 | 63.8 ± 8.2 | 0.152 |
BMI, kg/m2 | 23.6 ± 2.8 | 23.2 ± 3.2 | 20.7 ± 3.1 | 24.0 ± 2.9 | 0.006 |
SBP, mmHg | 131 ± 18 | 131 ± 16 | 131 ± 15 | 125 ± 17 | 0.681 |
DBP, mmHg | 80 ± 9 | 81 ± 11 | 81 ± 9 | 76 ± 12 | 0.333 |
Spirometry | |||||
FVC%pred | 94.3 ± 21.2 | 75.3 ± 16.9 | 64.1 ± 16.2 | 105.2 ± 13.2 | <0.0001 |
FEV1%pred | 81.9 ± 21.3 | 48.1 ± 16.8 | 42.5 ± 18.2 | 106.8 ± 10.3 | <0.0001 |
FEV1/FVC | 70.3 ± 7.5 | 50.7 ± 8.1 | 51.7 ± 12.7 | 83.1 ± 4.8 | <0.0001 |
MVV%pred | 80.0 ± 18.6 | 48.1 ± 20.7 | 40.5 ± 19.2 | 99.4 ± 13.2 | <0.0001 |
Vascular evaluation | |||||
PWV, cm/s | 1657.2 ± 395.6 | 1638.4 ± 328.8 | 1830.3 ± 554.6 | 1432.4 ± 286.4 | 0.040 |
FMD (% ) | 7.09 ± 3.30 | 5.36 ± 1.61 | 5.45 ± 2.71 | 7.24 ± 3.30 | 0.063 |
Inflammatory markers | |||||
IL-10, pg/ml | 448.4 (383.4-643.1) | 438.8 (368.1-553.1) | 462.7 (395.5-530.5) | 500.5 (383.7–543.0) | 0.472 |
IL-17, pg/ml | 33.4 (5.9–58.6) | 11.1 (0.0-37.1) | 11.0 (0.9–17.7) | 17.5 (8.1–23.4) | 0.279 |
IL-6, pg/ml | 27.5 (18.9–37.5) | 30.9 (18.5–39.1) | 28.2 (18.0-37.9) | 32.7 (21.6–56.8) | 0.472 |
NP, nmol/l | 8.1 ± 2.6 | 7.8 ± 2.6 | 9.0 ± 2.6 | 5.9 ± 2.7 | 0.006 |