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Table 6 LEAD reference equations for lung volumes in males and females

From: Updated reference values for static lung volumes from a healthy population in Austria

LEAD

Male (n = 2397)

Female (n = 2974)

Z-score

KS p -value

95% CI

% > ULN

% < LLN

Z-score

KS p -value

95% CI

% > ULN

% < LLN

(mean ± SD)

(mean ± SD)

TLC

 total

0.00 ± 1.00

0.5

[-0.04, 0.04]

4.96

5.01

0.00 ± 1.00

0.4

[-0.04, 0.04]

5.08

5.21

  ≤ 18 years

0.00 ± 1.00

0.6

[-0.06, 0.07]

5.30

4.87

0.00 ± 1.01

0.4

[-0.05, 0.06]

5.61

4.81

 18–65 years

0.00 ± 0.99

 > 0.9

[-0.06, 0.05]

4.63

4.86

0.00 ± 0.98

0.14

[-0.05, 0.05]

4.30

5.44

  > 65 years

0.01 ± 1.10

 > 0.9

[-0.14, 0.17]

5.56

6.57

0.00 ± 1.06

0.7

[-0.13, 0.14]

7.17

5.91

FRC

 total

0.00 ± 1.00

0.7

[-0.04, 0.04]

5.13

4.96

0.00 ± 1.00

0.2

[-0.04, 0.04]

5.28

4.51

  ≤ 18 years

0.00 ± 1.00

0.5

[-0.06, 0.07]

5.09

5.09

0.00 ± 1.01

0.3

[-0.06, 0.05]

6.01

3.53

 18–65 years

-0.01 ± 1.00

0.8

[-0.07, 0.04]

5.10

5.10

0.00 ± 0.99

0.9

[-0.05, 0.05]

4.70

5.23

  > 65 years

0.06 ± 0.99

0.6

[-0.08, 0.19]

5.56

3.54

0.01 ± 1.03

0.6

[-0.12, 0.14]

5.06

5.06

RV

 total

0.00 ± 1.00

0.5

[-0.04, 0.04]

4.92

4.30

0.00 ± 1.00

0.081

[-0.04, 0.04]

5.99

4.10

  ≤ 18 years

-0.01 ± 0.99

0.5

[-0.08, 0.05]

4.22

4.22

0.00 ± 1.00

0.3

[-0.06, 0.05]

5.77

3.69

 18–65 years

0.00 ± 1.00

0.9

[-0.05, 0.06]

5.18

4.24

0.00 ± 0.99

0.2

[-0.05, 0.05]

5.97

4.36

  > 65 years

0.02 ± 1.02

0.7

[-0.13, 0.16]

6.57

5.05

0.01 ± 1.06

0.5

[-0.13, 0.14]

7.17

4.64

RV/TLC

 total

0.00 ± 1.00

0.2

[-0.04, 0.04]

4.63

4.55

0.00 ± 1.00

0.7

[-0.04, 0.04]

5.55

4.47

 ≤ 18 years

-0.01 ± 0.99

0.4

[-0.08, 0.05]

4.11

4.87

-0.01 ± 1.00

 > 0.9

[-0.06, 0.05]

4.89

4.41

 18–65 years

0.01 ± 1.00

 > 0.9

[-0.05, 0.06]

5.10

4.39

0.00 ± 1.00

0.3

[-0.05, 0.06]

6.04

4.43

  > 65 years

0.00 ± 1.00

0.5

[-0.13, 0.14]

4.04

4.04

0.00 ± 1.05

0.8

[-0.14, 0.13]

5.91

5.06

IC

 total

0.00 ± 1.00

0.15

[-0.04, 0.04]

5.26

5.05

0.00 ± 1.00

0.8

[-0.04, 0.04]

5.18

4.91

  ≤ 18 years

0.00 ± 1.00

0.5

[-0–07, 0.06]

5.09

4.87

0.00 ± 1.00

0.9

[-0.05, 0.06]

5.05

5.21

 18–65 years

0.01 ± 1.00

0.6

[-0.04, 0.07]

5.65

4.94

0.00 ± 0.99

0.7

[-0.05, 0.05]

5.30

4.43

  > 65 years

-0.06 ± 1.00

0.4

[-0.20, 0.08]

3.54

6.57

-0.02 ± 1.03

0.6

[-0.15, 0.11]

5.06

6.33

ERV

 total

0.00 ± 0.99

0.9

[-0.04, 0.04]

5.42

4.88

0.00 ± 1.00

0.3

[-0.04, 0.04]

4.77

4.71

  ≤ 18 years

0.02 ± 0.97

0.5

[-0.04, 0.08]

5.19

3.57

0.00 ± 0.99

0.3

[-0.05, 0.06]

5.05

4.41

 18–65 years

-0.02 ± 1.01

 > 0.9

[-0.07, 0.04]

5.41

5.88

0.00 ± 1.00

0.3

[-0.05, 0.05]

4.50

4.83

  > 65 years

0.04 ± 1.01

 > 0.9

[-0.10, 0.18]

6.57

4.55

-0.02 ± 1.02

0.4

[-0.15, 0.11]

5.06

5.49

  1. Abbreviations: CI confidence interval of mean Z-scores, ERV expiratory reserve volume, FRC functional residual capacity, IC inspiratory capacity, KS Kolmogorov–Smirnov test for distribution of mean Z-scores, LLN lower limit of normal, RV residual volume, TLC total lung capacity, ULN upper limit of normal