Fig. 7
From: Loss of ZNF451 mediates fibroblast activation and promotes lung fibrosis
PDGFB-neutralizing antibody attenuates ZNF451 depletion-induced lung fibroblast activation. A Immunoblots of phosphorylated and total AKT in lung fibroblasts in response to PDGFB antibody stimuli. B Migration analysis of lung fibroblasts from BLM-challenged WT or Znf451-/- mice treated with or without PDGFB antibody. C RT‒PCR of mRNA expression of fibrosis genes in lung fibroblasts from BLM-challenged WT or Znf451-/- mice treated with or without PDGFB antibody. D Representative images of α-SMA immunostaining in lung fibroblasts from BLM-challenged WT or Znf451-/- mice treated with or without PDGFB antibody. Scale bars, 50 μm