Fig. 2
From: Loss of ZNF451 mediates fibroblast activation and promotes lung fibrosis
Genetic deletion of ZNF451 attenuates BLM-induced PF. A Schematic overview of the experimental design for (C-F). B Immunofluorescence staining of ZNF451 in lung tissue sections from WT or Znf451-/- mice. Scale bars, 50 μm. C Masson staining was performed to evaluate fibrotic changes in PBS- or BLM-challenged WT mice or Znf451-/- mice (n = 6 per group). Scale bars, 100 μm. D Cst was measured to evaluate the lung function of PBS- or BLM-challenged WT mice or Znf451-/- mice. E Hydroxyproline content in PBS- or BLM-challenged WT mice or Znf451-/- mouse lungs. F RT‒PCR of mRNA expression of fibrosis genes in PBS- or BLM-challenged WT mice or Znf451-/- mice lungs