The endothelium: gatekeeper to lung ischemia-reperfusion injury

Respiratory Research

Table 1 Potential therapies for lung ischemia-reperfusion injury

Potential Therapies	Targets	References
Controlled reperfusion and ventilation	Endothelium (general)	106, 107
Sevoflurane	Glycocalyx	35, 108
Interferon-β-1a	Multiple cells including ECs	109
GSK2193874	TRPV4	110, 111
GSK2220961	TRPV4	54
GSK2337429	TRPV4	54
GSK2798745	TRPV4	112–114
HC-067047	TRPV4	111
Mibefradil	T-type Ca²⁺ channels	115
Flunarizine	T-type Ca²⁺ channels	115
Probenecid	Panx1	79
Carbenoxolone	Panx1	79
Imatinib	Abl tyrosine kinase	116, 117
3-methyladenine	Autophagy	118–120
S1P	S1P receptor 1	92–97
EVLP	Endothelium (general)	121–123
EVLP + A2AR agonists	Endothelium (general), A2AR	121–127
EVLP + A2BR agonists	Endothelium (general), A2BR	128–129
EVLP + S1P and SK inhibitors	Endothelium (general), S1PR, SK	94

Abbreviations: A2AR, adenosine 2 A receptor; A2BR, adenosine 2B receptor; EVLP, ex vivo lung perfusion; Panx1, pannexin 1; S1P, sphingosine-1-phosphate; SK, sphingosine kinase; TRPV4, transient receptor potential cation channel subfamily V member 4

ISSN: 1465-993X