Table 3 The origins and targets of the main soluble mediators in pulmonary hypertension
From: Novel insights and new therapeutic potentials for macrophages in pulmonary hypertension
| Â | Produced by | Affects |
|---|---|---|
IL-1 | Fibroblast, macrophage, neutrophil, T cell, VSMCs | VSMCs, macrophage |
IL-6 | Fibroblast, VSMCs, Th1 cell, macrophage | Macrophage, Th1 cell, Th2 cell |
IL-8 | VSMC, macrophage, VECs | Neutrophil |
IL-10 | Th2 cell, B-cell | Macrophage, Th1 cell, VSMCs |
MIF | Fibroblast, macrophage, VECs | VSMCs, VECs |
CCL2 | Fibroblast, VECs, VSMCs | Macrophage |
CCL5 | Fibroblast, VECs | Macrophage |
CX3CL1 | Macrophage, VECs | Macrophage, VSMCs |
CXCL12 | Fibroblast, VECs | Macrophage |