Table 1 Genetic or pharmacological targets associated with macrophages in the PH model
From: Novel insights and new therapeutic potentials for macrophages in pulmonary hypertension
Author | Year | Main result | Model | Species | Intervention | Reference |
|---|---|---|---|---|---|---|
Yaku et al. | 2022 | Regnase-1 regulates IL-6 and PDGF in alveolar macrophages. | Hypoxia | Mouse | Genetic knockout | [41] |
Yu et al. | 2022 | Selective BTK inhibitor BGB-3111 regulates macrophage recruitment and polarization. | MCT | Rat | BGB-3111 | [36] |
Rong et al. | 2022 | Caspase-8 deletion or pharmacologically blocking affects the proinflammatory factors secreting in M1 macrophages. | SU5416/Hypoxia, MCT | Mouse, rat | Genetic knockout and inhibitor (Z-IETD-FMK) | [38] |
Kojima et al. | 2019 | HIF-1α deletion in myeloid suppresses macrophage infiltration. | Hypoxia | Mouse | Genetic knockout | [33] |
Hu et al. | 2019 | Hif-2 inhibitor PT2567 attenuated monocyte recruitment. | Hypoxia | Rat | PT2567 | [35] |
Xi et al. | 2019 | SGK1 knockout inhibits proinflammatory cytokines expression and inflammatory infiltration of macrophage. | Hypoxia | Mouse | Genetic knockout | [39] |
Amsellem et al. | 2017 | Inactivation of CX3CR1 modulates monocyte recruitment and macrophage phenotype. | Hypoxia | Mouse | Genetic knockout and CX3CR1 antagonist F1 | [40] |
Barman et al. | 2014 | Nox4 colocalizes with monocyte markers. Nox4 inhibitor VCC202273 attenuates PH progression. | SU5416/Hypoxia, MCT | Mouse, rat | VCC202273 | [37] |
Tian et al. | 2013 | Blocking macrophage Leukotriene B4 abrogates endothelial injury. | SU5416/Hypoxia, MCT | Rat | LTA4H inhibitor Bestatin | [32] |