Table 1 Baseline characteristics of participants with and without IOS-BDR in overall participant
|  | Overall participants (n = 466) | Participants without IOS-BDR (n = 374) | Participants with IOS-BDR (n = 92) | P-Value |
|---|---|---|---|---|
Age, years | 62.3 ± 8.0 | 62.3 ± 8.0 | 62.2 ± 7.9 | 0.923 |
Male. n (%) | 372 (79.8) | 300 (80.2) | 72 (78.3) | 0.676 |
BMI, kg/m2 | 22.4 ± 3.2 | 22.4 ± 3.2 | 22.5 ± 3.3 | 0.830 |
Pack-years | 30.4 ± 32.9 | 30.2 ± 32.6 | 31.5 ± 34.1 | 0.733 |
Smoking status, n (%) | Â | Â | Â | 0.757 |
 Never smoker | 129 (27.7) | 104 (27.8) | 25 (27.2) |  |
 Ever smoker | 103 (22.1) | 85 (22.7) | 18 (19.6) |  |
 Current smoker | 234 (50.2) | 185 (49.5) | 49 (53.3) |  |
Chronic respiratory symptoms, n (%) | Â | Â | Â | Â |
 Cough | 129 (27.7) | 95 (25.5) | 34 (37.0) | 0.028 |
 Phlegm | 179 (38.5) | 136 (36.5) | 43 (46.7) | 0.070 |
 Wheeze | 61 (13.1) | 40 (10.7) | 21 (22.8) | 0.002 |
 Dyspnea | 153 (32.9) | 116 (31.1) | 37 (40.2) | 0.095 |
Family history of respiratory diseases, n (%) | 67 (14.4) | 52 (13.9) | 15 (16.3) | 0.557 |
occupational exposure, n (%) | 77 (16.5) | 61 (16.3) | 16 (17.4) | 0.802 |
Biomass exposure, n (%) | 133 (28.5) | 103 (27.5) | 30 (32.6) | 0.335 |
History of asthma, n (%) | 7 (1.5) | 3 (0.8) | 4 (4.4) | 0.041 |
mMRC scores | 0.4 ± 0.6 | 0.4 ± 0.6 | 0.5 ± 0.7 | 0.047 |
CAT scores | 2.8 ± 3.4 | 2.5 ± 3.0 | 3.9 ± 4.5 | 0.009 |
LAA− 950 | 2.6 ± 4.5 | 2.4 ± 4.3 | 4.0 ± 5.1 | 0.038 |
LAA− 856 | 15.4 ± 17.2 | 14.2 ± 16.4 | 22.4 ± 20.2 | 0.008 |
Exacerbations in previous year* | 0.35 ± 0.84 | 0.33 ± 0.84 | 0.44 ± 0.83 | 0.338 |
Follow-up, month | 23.5 ± 0.7 | 23.5 ± 0.7 | 23.4 ± 0.6 | 0.262 |