Respiratory Research

Table 7 Correlation between urinary MEHHP and a panel of inflammatory markers

From: Increased di-(2-ethylhexyl) phthalate exposure poses a differential risk for adult asthma clusters

Urinary DEHP metabolite	Stratification	Status	MEHP + MEHHP	MEHP	MEHHP	HEL	4-HNE	S1P	C1P	IL-1β	IL-6	IL-8	IL-10	IL-13	IL-17	IFN-γ	MCP-1	MIP-1β
Urinary DEHP metabolite	Stratification	Status	ρ	ρ	ρ	ρ	ρ	ρ	ρ	ρ	ρ	ρ	ρ	ρ	ρ	ρ	ρ	ρ
MEHHP	Asthma	+	0.92^***	0.63^***	NA					-0.17^*	-0.20^*	-0.16^*		-0.17^*	-0.16^*
	Asthma	-	0.94^***	0.59^***	NA	0.16^*	0.23^***								0.14^*
	Asthma-phenotypic clusters	A	0.84^***		NA
		B	0.94^***	0.58^***	NA								-0.34^*	-0.32^*
		C	0.95^***	0.81^***	NA
		D	0.84^***	0.43^*	NA
		E			NA
		F	0.97^***	0.77^***	NA
	Asthma severity^a	++	0.92^***	0.69^***	NA
	Asthma severity^a	+	0.92^***	0.59^***	NA					-0.31^**	-0.39^***	-0.26^*			-0.32^**	-0.31^**	-0.23^*	-0.25^*
	Atopic	+	0.93^***	0.65^***	NA	0.17^*					-0.18^*			-0.19^*	-0.18^*
	Atopic	-	0.87^***	0.48^**	NA			-0.56^*				-0.37^*
	Asthma/T2DM	+	0.98^***	0.69^**	NA			-0.59^*		-0.54^*	-0.66^**
	Asthma/T2DM	-	0.91^***	0.63^***	NA								-0.19^*	-0.19^*
	Asthma/hypertension	+	0.86^***	0.47^***	NA
	Asthma/hypertension	-	0.94^***	0.68^***	NA	0.20^*					-0.29^**	-0.21^*		-0.28^**				-0.19^*
	Asthma/T2DM/hypertension	+	0.98^***	0.77^**	NA			-0.68^*			-0.90^***			0.73^*
	Asthma/T2DM/hypertension	-	0.93^***	0.67^***	NA	0.23^*					-0.27^**	-0.20^*	-0.20^*	-0.26^**				-0.19^*
	Asthma/allergic rhinitis	+	0.93^***	0.67^***	NA									-0.20^*
	Asthma/allergic rhinitis	-	0.89^***	0.54^***	NA			-0.55^**		-0.31^*

NA, not applicable
^a ++, severe/very severe; +, mild/moderate
^*P < 0.05; ^**P < 0.01; ^***P < 0.001

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ISSN: 1465-993X

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