Respiratory Research

Table 6 Correlation between urinary MEHP and a panel of inflammatory markers

From: Increased di-(2-ethylhexyl) phthalate exposure poses a differential risk for adult asthma clusters

Urinary DEHP metabolite	Stratification	Status	MEHP + MEHHP	MEHP	MEHHP	HEL	4-HNE	S1P	C1P	IL-1β	IL-6	IL-8	IL-10	IL-13	IL-17	IFN-γ	MCP-1	MIP-1β
Urinary DEHP metabolite	Stratification	Status	ρ	ρ	ρ	ρ	ρ	ρ	ρ	ρ	ρ	ρ	ρ	ρ	ρ	ρ	ρ	ρ
MEHP	Asthma	+	0.84^***	NA	0.63^***	0.18^*				-0.27^***	-0.34^***	-0.25^**		-0.20^*	-0.22^**	-0.20^*	-0.17^*	-0.30^***
	Asthma	-	0.81^***	NA	0.59^***		0.22^***
	Asthma-phenotypic clusters	A	0.75^***	NA			-0.54^**				-0.69^***			-0.44^*	-0.48^*			-0.48^*
		B	0.78^***	NA	0.58^***					-0.36^*		-0.35^*	-0.29^*
		C	0.93^***	NA	0.81^***
		D	0.78^***	NA	0.43^*								0.55^**
		E		NA
		F	0.87^***	NA	0.77^***						-0.40^*
	Asthma severity^a	++	0.88^***	NA	0.69^***	0.29^*								-0.29^*
	Asthma severity^a	+	0.81^***	NA	0.59^***					-0.41^***	-0.48^***	-0.39^***			-0.30^**	-0.31^**	-0.24^*	-0.45^***
	Atopic	+	0.85^***	NA	0.65^***					-0.27^**	-0.30^***	-0.24^**			-0.20^*			-0.26^**
	Atopic	-	0.78^***	NA	0.48^**		-0.34^*				-0.52^**			-0.42^*				-0.46^*
	Asthma/T2DM	+	0.81^***	NA	0.69^**						-0.52^*
	Asthma/T2DM	-	0.85^***	NA	0.63^***	0.25^**				-0.27^***	-0.32^***	-0.26^**		-0.21^*	-0.21^*	-0.21^*		-0.29^***
	Asthma/hypertension	+	0.79^***	NA	0.47^***		-0.28^*										-0.30^*
	Asthma/hypertension	-	0.86^***	NA	0.68^***					-0.31^***	-0.37^***	-0.35^***		-0.29^**	-0.18^*			-0.38^***
	Asthma/T2DM/hypertension	+	0.85^***	NA	0.77^**						-0.71^*			0.67^*
	Asthma/T2DM/hypertension	-	0.85^***	NA	0.67^***					-0.30^**	-0.37^***	-0.34^***		-0.27^**	-0.19^*			-0.38^***
	Asthma/allergic rhinitis	+	0.85^***	NA	0.67^***					-0.27^**	-0.30^**	-0.28^**			-0.19^*	-0.21^*		-0.32^***
	Asthma/allergic rhinitis	-	0.80^***	NA	0.54^***	0.33^*					-0.45^**			-0.36^*	-0.30^*

NA, not applicable
^a ++, severe/very severe; +, mild/moderate
^*P < 0.05; ^**P < 0.01; ^***P < 0.001

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