Respiratory Research

Table 5 Correlation between urinary MEHP + MEHHP and a panel of inflammatory markers

From: Increased di-(2-ethylhexyl) phthalate exposure poses a differential risk for adult asthma clusters

Urinary DEHP metabolite	Stratification	Status	MEHP + MEHHP	MEHP	MEHHP	HEL	4-HNE	S1P	C1P	IL-1β	IL-6	IL-8	IL-10	IL-13	IL-17	IFN-γ	MCP-1	MIP-1β
Urinary DEHP metabolite	Stratification	Status	ρ	ρ	ρ	ρ	ρ	ρ	ρ	ρ	ρ	ρ	ρ	ρ	ρ	ρ	ρ	ρ
MEHP + MEHHP	Asthma	+	NA	0.84^***	0.92^***	0.19^*				-0.24^**	-0.31^***	-0.22^**		-0.20^**	-0.22^**	-0.21^**	-0.18^*	-0.22^**
	Asthma	-	NA	0.81^***	0.94^***	0.17^**	0.27^***
	Asthma-phenotypic clusters	A	NA	0.75^***	0.84^***						-0.61^**							-0.54^**
		B	NA	0.78^***	0.94^***					-0.32^*	-0.32^*	-0.30^*	-0.35^*	-0.32^*	-0.29^*
		C	NA	0.93^***	0.95^***
		D	NA	0.78^***	0.84^***								0.39^*
		E	NA
		F	NA	0.87^***	0.97^***
	Asthma severity^a	++	NA	0.88^***	0.92^***									-0.27^*
	Asthma severity^a	+	NA	0.81^***	0.92^***			-0.26^*		-0.40^***	-0.50^***	-0.35^***			-0.37^***	-0.38^***	-0.30^**	-0.38^***
	Atopic	+	NA	0.85^***	0.93^***	0.21^*				-0.21^*	-0.27^**	-0.19^*		-0.19^*	-0.22^*	-0.17^*		-0.17^*
	Atopic	-	NA	0.78^***	0.87^***						-0.54^**					-0.38^*		-0.48^**
	Asthma/T2DM	+	NA	0.81^***	0.98^***						-0.66^**
	Asthma/T2DM	-	NA	0.85^***	0.91^***	0.26^**				-0.22^**	-0.27^***	-0.20^*		-0.22^**	-0.21^*	-0.21^*	-0.18^*	-0.20^*
	Asthma/hypertension	+	NA	0.79^***	0.86^***										-0.29^*
	Asthma/hypertension	-	NA	0.86^***	0.94^***	0.24^*		-0.26^*		-0.26^**	-0.37^***	-0.31^***		-0.30^***	-0.19^*	-0.21^*		-0.30^***
	Asthma/T2DM/hypertension	+	NA	0.85^***	0.98^***			-0.68^*	-0.93^**		-0.89^***			0.69^*
	Asthma/T2DM/hypertension	-	NA	0.85^***	0.93^***	0.27^**		-0.25^*		-0.25^**	-0.35^***	-0.30^**		-0.28^**	-0.19^*	-0.21^*		-0.31^**
	Asthma/allergic rhinitis	+	NA	0.85^***	0.93^***					-0.20^*	-0.26^**	-0.21^*		-0.19^*	-0.21^*	-0.21^*		-0.22^*
	Asthma/allergic rhinitis	-	NA	0.80^***	0.89^***			-0.53^**		-0.33^*	-0.44^**

NA, not applicable
^a ++, severe/very severe; +, mild/moderate
^*P < 0.05; ^**P < 0.01; ^***P < 0.001

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ISSN: 1465-993X

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