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Table 4 Asthma status classifications in relation to DEHP exposures

From: Increased di-(2-ethylhexyl) phthalate exposure poses a differential risk for adult asthma clusters

Urinary metabolites

Severe/very severe vs.

control (n = 36/33)

 

Mild/moderate vs.

control (n = 44/33)

 

Atopic asthma vs.

control (n = 66/131)

 

Non-atopic asthma vs.

control (n = 14/131)

ORs

P-valuea

 

ORs

P-valuea

 

ORs

P-valueb

 

ORs

P-valueb

Model1

MEHP

1.38

0.07

 

1.33

0.10

 

1.56

< 0.001*

 

1.61

0.002*

Model2

MEHHP

3.85

< 0.001*

 

3.60

< 0.001*

 

2.81

< 0.001*

 

3.19

< 0.001*

 

MEHHP/MEHP

1.07

0.22

 

1.05

0.34

 

1.02

0.60

 

1.06

0.11

Model3

MEHP + MEHHP

3.19

< 0.001*

 

2.98

< 0.001*

 

2.69

< 0.001*

 

3.04

< 0.001*

Urinary metabolites

Asthma/T2DM vs.

control (5/33)

 

Asthma without T2DMvs

control (n = 75/33)

 

Asthma/HPTS vs.

control (n = 14/29)

 

Asthma without HPTS vs.

control (n = 66/29)

ORs

P-valuec

 

ORs

P-valuec

 

ORs

P-valuec

 

ORs

P-valuec

Model1

MEHP

1.18

0.51

 

1.41

0.06

 

1.11

0.63

 

1.43

0.07

Model2

MEHHP

4.40

< 0.001*

 

4.45

< 0.001*

 

4.50

0.001*

 

5.85

< 0.001*

 

MEHHP/MEHP

1.10

0.16

 

1.06

0.27

 

1.14

0.04

 

1.06

0.33

Model3

MEHP + MEHHP

3.18

0.003*

 

3.51

< 0.001*

 

3.02

0.004*

 

3.95

< 0.001*

Urinary metabolites

Asthma/T2DM/HPTS

vs. control (n = 1/29)

 

Asthma without T2DM & HPTS

vs. control (n = 62/29)

 

Asthma/allergic rhinitis

vs. control (n = 52/27)

 

Asthma without allergic rhinitis

vs. control (n = 28/27)

ORs

P-valuec

 

ORs

P-valuec

 

ORs

P-valuec

 

ORs

P-valuec

Model1

MEHP

0.70

0.41

 

1.39

0.15

 

2.01

0.03

 

1.62

0.06

Model2

MEHHP

5.36

0.01*

 

7.02

< 0.001*

 

19.98

< 0.001*

 

10.62

< 0.001*

 

MEHHP/MEHP

1.25

0.02

 

1.09

0.23

 

1.04

0.65

 

1.08

0.24

Model3

MEHP + MEHHP

2.85

0.07

 

4.20

< 0.001*

 

10.47

< 0.001*

 

6.45

< 0.001*

  1. T2DM, Type 2 Diabetes Mellitus
  2. HPTS, hypertension
  3. a Multinomial logistic regression, adjusted for age, atopy, education, and household income
  4. b Multinomial logistic regression, adjusted for age, BMI, education, and household income
  5. c Multinomial logistic regression, adjusted for age, BMI, atopy, education, and household income
  6. *To minimize the risk of type I errors in our multiple comparison study, we set the α level to 0.01666667 (0.05/3) using the Bonferroni correction method
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Respiratory Research

ISSN: 1465-993X

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