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Table 3 Current asthma and its phenotypic clusters in relation to DEHP exposures

From: Increased di-(2-ethylhexyl) phthalate exposure poses a differential risk for adult asthma clusters

Urinary metabolites

Case vs. control

(n = 80/33)

 

Cluster A/control

(n = 14/143)

 

Cluster B/control

(n = 23/143)

 

Cluster C/control

(n = 13/143)

ORs

P-valuea

 

OR

P-valueb

 

OR

P-valueb

 

OR

P-valueb

Model 1

MEHP

1.39

0.07

 

1.57

0.01

 

1.26

0.11

 

1.78

< 0.001*

Model 2

MEHHP

4.49

< 0.001*

 

2.86

< 0.001*

 

1.90

0.003

 

2.94

< 0.001*

 

MEHHP/MEHP

1.06

0.23

 

1.06

0.19

 

1.03

0.32

 

0.91

0.23

Model 3

MEHP + MEHHP

3.50

< 0.001*

 

2.83

< 0.001*

 

1.87

0.003

 

2.92

< 0.001*

Urinary metabolites

Cluster D/control

(n = 5/143)

 

Cluster E/control

(n = 4/143)

 

Cluster F/control

(n = 21/143)

  

OR

P-valueb

 

OR

P-valueb

 

OR

P-valueb

   

Model 1

MEHP

1.70

0.001*

 

1.79

0.02

 

1.57

0.004

   

Model 2

MEHHP

3.00

< 0.001*

 

3.42

< 0.001*

 

2.92

< 0.001*

   
 

MEHHP/MEHP

0.99

0.89

 

1.10

0.16

 

1.04

0.35

   

Model 3

MEHP + MEHHP

2.95

< 0.001*

 

3.31

< 0.001*

 

2.75

< 0.001*

   
  1. a Multiple logistic regression, adjusted for age, BMI, atopy, education, and household income; the significance level (α) was set at 0.05
  2. b Multinomial logistic regression, adjusted for education and household income; to reduce the potential for type I errors in our multiple comparison study, we set the α level to 0.00238095 (0.05/21) using the Bonferroni correction method
  3. *The model exhibited statistical significance
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Respiratory Research

ISSN: 1465-993X

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