Table 3 Semi-quantitative histological analysis

Histological Patterns (%), median (range)

 Normal tissue

100 (95–100)

10 (0–55)^A

2.5 (0–50)^A

10 (0–50)

0 (0–50)^B

2.5 (0–40)^B

 Exudative DAD

0

57.5 (10–100)^A

60 (28–100)^A

55 (35–93)

60 (28–100)

60 (30–100)

 Fibroproliferative DAD

0

0 (0–40)^A

0 (0–45)^A

2.5 (0–10)

2.5 (0–45)

0 (0–45)

 Bronchopneumonia

0^B

0 (0–20)

0 (0–48)^B

0 (0–25)

0 (0–40)

0 (0–48)

Scores, median (range)

 Septal thickening

0 (0–1)

1 (0–3)^A

2 (1–3)^AB

1 (0–3)

1.5 (1–2)^B

2 (1–3)^B

 Oedema

0

1.5 (1–3)^A

2 (0–3)^A

1 (1–3)

2 (0–3)

2 (1–3)^B

 Inflammation

0 (0–1)

1 (1–2)^A

2 (1–3)^AB

2 (1–2)

2 (1–3)^B

2 (1–3)^B

 Hyaline Membrane

0

1 (0–2)^A

1 (1–3)^AB

1 (1–3)

1 (1–3)^B

2 (1–3)^B

 Alveolar Haemorrhage

0 (0–1)

1 (0–3)^A

1 (0–3)^AB

1 (0–3)

1 (0–3)

1 (0–3)

 Proliferation of type II pneumocytes

0

1 (0–2)^A

1 (0–3)^A

1.5 (0–3)

2 (1–3)

1 (1–3)

Inflammation pattern, n (%)

 Absent

23 (85.5%)

0

0

0

0

0

 Neutrophilic

0

5 (16.7%)

6 (12.8%)

1 (12.5%)

2 (14.3%)

3 (12%)

 Lymphomononuclear

4 (14.8%)

11 (36.7%)

11 (23.4%)

2 (25%)

3 (21.4%)

6 (24%)

 Mixed

0

14 (46.7%)

30 (63.8%)

5 (62.5%)

9 (64.3%)

16 (64%)