Fig. 3

Clinical characteristics are associated with upper and lower airway Simpson diversity. A.. Older age is associated with greater oral wash Simpson diversity. Oral wash 1 and oral wash 2 are illustrated by shape, and the regression lines represent the association between older age and greater Simpson diversity (GEE, CE 0.0022, 95% CI [0.00024, 0.0042], p = 0.022). B. Older age is associated with greater nasopharyngeal Simpson diversity. The regression line represents the association between older age and greater Simpson diversity (LR, CE 0.016, 95% CI [0.0032, 0.029], p = 0.019). C. Current tobacco use is associated with greater lung and bronchus Simpson diversity (GEE, CE 0.22, 95% CI [0.17, 0.28], p < 0.0001). D. Last professional dental cleaning more than 6 months prior to surgery (vs. within the last 6 months) was associated with lower lung and bronchus Simpson diversity (GEE, CE 0.21, 95% CI [0.12, 0.29], p < 0.0001). Edentulous subjects were excluded from this analysis. Data were dichotomized at the 6 month timepoint for the GEE analysis, however three timepoints (within the last 6 months, 6–12 months ago, and more than 1 year ago) are presented here for illustrative purposes. E. Lung adenocarcinoma (vs. other pathologic finding) was associated with lower lung and bronchus Simpson diversity (GEE, CE -0.11, 95% CI [-0.21, -0.015], p = 0.024)