Table 1 Characteristics of the enrolled studies
Title | Author | Year | Journal | Study Design | Study duration months | N° of patients | Tot Number of SSc patients | N° of control | SSc definition | Diffuse cutaneous SSc % | female % | Mean age, years (sd) |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
Histopathologic Subsets of Fibrosing Alveolitis in Patients with Systemic Sclerosis and Their Relationship to Outcome | D. W. Bouros, A. U.: Nicholson, A. G.: Colby, et al. | 2002 | Am J Respir Crit Care Med | retrospective cohort | 144 | 80 | 80 | 0 | ARA 1980 | 30 | NA | 46 (11) |
Suppressed signal transduction in the bronchial epithelium of patients with systemic sclerosis | M. A. Sehlstedt, G. N. Nilsson, K. Blomberg, A. et al. | 2009 | Respir Med | retrospective cohort | NA | 40 | 23 | 17 | ARA 1980 | 75 | 78 | 64 (10) |
Arterial and interstitial remodelling processes in non-specific interstitial pneumonia: systemic sclerosis versus idiopathic | E. F. P. de Carvalho, E. R. de Souza, R. A’B Saber, et al. | 2008 | Histopathology | retrospective cohort | 324 | 40 | 18 | 22 | ARA 1980 | 78 | 100 | 45,82 (9,04) |
Idiopathic and collagen vascular disease nonspecific interstitial pneumonia: Clinical significance of remodeling process | C. H. C. P. FelÃŒcio, E. R. Capelozzi, V. L. | 2007 | Lung | retrospective cohort | 288 | 41 | 10 | 20 | NA | NA | 80 | 49.7 (12,7) |
Anti-fibrotic effects of pirfenidone by interference with the hedgehog signalling pathway in patients with systemic sclerosis-associated interstitial lung disease | H. Z. Xiao, G. F. Liao, X. P. Li, et al. | 2018 | Int J Rheum Dis | clinical trial | NA | 35 | 25 | 10 | ARA 1980 | 100 | 84 | 48,1 (12,8) |
Association of Interferon- and transforming growth factor b-regulated genes and macrophage activation with systemic sclerosis-related progressive lung fibrosis | R. B. S.-B. Christmann, P. Stifano, G. Borges, C. L. et al. | 2014 | Arthritis Rheumatol | prospective cohort | 60 | 25 | 21 | 4 | ARA 1980 | 52 | 100 | 44 (9,4) |
Clinical Features of Idiopathic Interstitial Pneumonia with Systemic Sclerosis-Related Autoantibody in Comparison with Interstitial Pneumonia with Systemic Sclerosis | H. H. Yamakawa, E. Kitamura, H. Yamanaka, et al. | 2016 | PLoS One | retrospective cohort | NA | 72 | 25 | 32 | ACR 2013 criteria | NA | NA | NA |
Structural features of interstitial lung disease in systemic sclerosis | N. K. M. Harrison, (A) R. Corrin, (B) Soosay, G. et al. | 1991 | Am Rev Respir Dis | retrospective cohort | NA | 56 | 34 | 22 | ARA 1980 | 58.8 | 76.5 | 46 (3) |
Parenchymal and vascular interactions in the pathogenesis of nonspecific interstitial pneumonia in systemic sclerosis and idiopathic interstitial pneumonia | E. P. Franco de Carvalho, E. R. de Souza, R. Muxfeldt A’b Saber et al. | 2008 | Respiration | retrospective cohort | NA | 40 | 18 | 22 | ARA 1980 | 78 | 100 | 45.82 (2.19) |
Clinically significant interstitial lung disease in limited scleroderma: histopathology, clinical features, and survival | A. S. Fischer, J. J. Groshong, S. D. Cool et al. | 2008 | Chest | retrospective cohort | NA | 22 | 22 | 0 | ACR 2013 criteria | 0,00 | 64 | NA |
A long-term prospective randomized controlled study of non-specific interstitial pneumonia (NSIP) treatment in scleroderma | D. S. B. Domiciano, E. Borges, C. T. Kairalla et al. | 2011 | Clin Rheumatol | prospective cohor | 30 | 18 | 18 | 0 | ARA 1980 | 55.6 | 100 | 43,94 (9,36) |
Centrilobular fibrosis: an underrecognized pattern in systemic sclerosis | R. B. B. de Souza, C. T. Capelozzi, V. L. Parra et al. | 2009 | Respiration | prospective cohor | 30 | 28 | 28 | 0 | ARA 1980 | 52,00 | 100 | 43,56 (9,23) |
Morphometric evaluation of nitric oxide synthase isoforms and their cytokine regulators predict pulmonary dysfunction and survival in systemic sclerosis | E. R. A. J. Parra, A. C. Silva, L. O. Souza, et al. | 2013 | Braz J Med Biol Res | prospective cohor | 30 | 23 | 23 | 0 | ARA 1980 | 52,65 | 100 | 44,61 (7,02) |
The major histopathologic pattern of pulmonary fibrosis in scleroderma is Nonspecific Interstitial Pneumonia | D. S. Kim, B. Yoo, J.S. Lee, et al. | 2002 | Sarcoidosis Vasculitis and Diffuse Lund Diseases | retrospective cohort | NA | 19 | 19 | 0 | ARA 1980 | NA | 68 | 42,3 (11,3) |