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Fig. 6 | Respiratory Research

Fig. 6

From: Single-cell analysis reveals alterations in cellular composition and cell-cell communication associated with airway inflammation and remodeling in asthma

Fig. 6

Characterization of stroma population in NC and AS groups. (A) A total of 8 clusters of stromal cells were identified. Each cell cluster was colored as indicated by the legend. (B) Stacked violin plots to visualize the expression level of signature gene markers in each cell population. (C) Left: the cell number of each cell cluster in NC and AS group; Right: representation of the relative cell proportion of each cell cluster, Fisher’s exact test computed significance of enrichment and highlighted with asterisks: *P < 0.05; **FDR < 0.05. (D) GSEA analysis identified significantly enriched signaling pathways in selected stromal cell clusters. All terms were significantly enriched (adjusted p-value < 0.05), dot size denoted -log10 (adjusted p-value) and normalized enrichment scores were shown in color legend. (E) GSEA plots depicting the enrichment of selected signaling pathways in Myo/SMC (left) and Igf1 + Fib (right) of AS group in comparison with NC group. Different signaling pathways were indicated by the color legend

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Respiratory Research

ISSN: 1465-993X

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