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Fig. 5 | Respiratory Research

Fig. 5

From: Single-cell analysis reveals alterations in cellular composition and cell-cell communication associated with airway inflammation and remodeling in asthma

Fig. 5

Characterization of myeloid population in NC and AS groups. (A) A total of 15 clusters of myeloid cells were identified. Each cell cluster was colored as indicated by the legend. (B) Stacked violin plots to visualize the expression level of signature gene markers in each cell population. (C) Left: the cell number of each cell cluster in NC and AS group; Right: representation of the relative cell proportion of each cell cluster, Fisher’s exact test computed significance of enrichment and highlighted with asterisks: *P < 0.05; **FDR < 0.05. (D) GSEA analysis identified significantly enriched signaling pathways in selected myeloid cell clusters. All terms were significantly enriched (adjusted p-value < 0.05), dot size denoted -log10 (adjusted p-value) and normalized enrichment scores (NES) were shown in color legend. Heatmap showing the DEGs involved in selected signaling pathways in (E) Int macro and (F) Alv macro C4. Log2FC and -log10 (adjusted p value) of gene were shown in color legend, enrichment score of signaling pathway was sorted and displayed in the bottom annotation bar

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Respiratory Research

ISSN: 1465-993X

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