Midregional proatrial naturetic peptide (MRproANP) and copeptin (COPAVP) as predictors of all-cause mortality in recently diagnosed mild to moderate COPD—results from COSYCONET

Table 2 Results of consecutive Cox regression analyses for mortality in patients with GOLD 0–2 and COPD diagnosis no more than 5 years prior to inclusion

Recently diagnosed mild to moderate COPD	COPAVP HR for upper quartile (9.18 pmol/L)		MRproADM HR for upper quartile (0.824 nmol/L)		MRproANP HR for upper quartile (97.3 pmol/L)		Fibrinogen HR for upper quartile (3.22 g/L)
	HR (95% CI)	P value	HR (95% CI)	P value	HR (95% CI)	P value	HR (95% CI)	P value
Model 1 Unadjusted, only four biomarkers	1.921 (1.025; 3.601)	0.042	1.658 (0.861; 3.191)	0.130	3.684 (1.902; 7.136)	< 0.001	1.717 (0.929; 3.172)	0.085
Model 2 Four biomarkers adjusted for COPD characteristics *	2.667 (1.306; 5.447)	0.007	0.758 (0.330; 1.739)	0.512	2.974 (1.364; 6.488)	0.006	1.354 (0.663; 2.768)	0.406
Model 3 Four biomarkers adjusted for COPD characteristics + further risk factors **	2.339 (1.077; 5.079)	0.032	0.744 (0.305; 1.814)	0.515	3.053 (1.355; 6.881)	0.007	1.387 (0.667; 2.885)	0.381
Model 4 final Four biomarkers adjusted for COPD characteristics + further risk factors + cardiovascular diseases, troponin & creatinine *	2.988 (1.111; 8.039)	0.030	1.222 (0.420; 3.556)	0.712	4.491 (1.577; 12.789)	0.005	1.030 (0.397; 2.674)	0.951

The significant p-values are in bold
Hazard ratios are given for the respective biomarkers in the upper quartile versus the three lower quartiles
^*Age, BMI, FEV1% predicted, TLCO % predicted, SGRQ total score, 6-min walking distance, ≥ 1 moderate/severe exacerbations in the previous year, smoking status, packyears, hypercapnia (PaCO2 > 55 mmHg), hypoxemia (PaO2 < 60 mmHg)
^**All variables of model 2 plus sex, hypertension, diabetes, hyperlipidemia, log HbA1c, and log CRP
^***All variables of model 3 plus heart failure, coronary artery disease, history of myocardial infarction, history of stroke, ankle-brachial index ≤ 0.90, log NT-proBNP, left-ventricular ejection fraction from echocardiography, troponin, creatinine

ISSN: 1465-993X