Fig. 4

CMPP-related module genes are correlated with neutrophil functions and inflammatory response pathways.  A The WGCNA used to analyze all the genes and identify the modules significantly related to traits. Heatmaps show the correlation between eigengenes and clinical traits. The cells are colored by the correlation according to the color legend. Each row corresponds to a module eigengene. Each cell contains the corresponding correlation and P value. B The Venn diagram displaying the black-DEGs overlapping in the black module and DEGs between CMPP and GMPP. C, D GO and KEGG enrichment of the black-DEGs genes. E CytoHubba-MCC was used to identify the top 10 hub genes in the network. The darker the orange color, the higher the score. F The relationship between DECs and hub black DEGs. G ROC curve constructed to study the predictive effect of the 10 hub genes on the diagnosis of CMPP.  AUC area under the curve, CI 95% confidence interval, ROC receiver operating characteristic curve, WGCNA weighted Gene Co-expression Network analysis. *P  < 0.05, ** P  < 0.01, *** P  < 0.001, **** P  < 0.0001