Fig. 3

Host transcriptional features of CMPP are correlated with neutrophil functions and inflammatory response pathways.  A Volcano plot of DEGs in CMPP and GMPP. The horizontal line at adj P  = 0.05; vertical line at |log 2 FC| = 1. Red and blue dots in volcano plot show upregulated and downregulated genes, respectively. B Heatmap showing the DEGs. The gradation of color represents the value of |lo g2 FC|. Hierarchical clustering classified samples into two clusters, namely the C1 cluster and the C2 cluster. C, D GO-Biological Process, KEGG enrichment analysis of the up regulated DEGs. E A violin plot showing the distribution of 22 types of immune cells in CMPP and GMPP. F, G Comparison of the infiltration of neutrophils between the two groups using other algorithms.  BP biological process, DEG differentially expressed gene, DEC differentially expressed cell, FC fold change, GO Gene Ontology, KEGG Kyoto Encyclopedia of Genes and Genomes, ssGSEA single-sample gene set enrichment analysis