Table 3 The potential therapeutic miRNAs in ARDS

Adverse

 miR-92a-3p

PTEN

NF-κB

Induce AMs activation

[302]

 miR-155-5p

SOCS5

JAK2/STAT3

Induce inflammation and apoptosis

[303]

 miR-210-3p

ATG7

Induce inflammation and apoptosis

[304]

 mir -146a-3p

SIRT1

NF-κB

Induce inflammation, apoptosis and oxidative stress

[305]

 miR-1224-5p

PPAR-γ

PPAR-γ/AMPKα

Induce inflammation and oxidative stress

[306]

 miR-23a-5p

HSP20

ASK1

Induce inflammation and oxidative stress

[307]

 miR-762

SIRT7

NF-κB

Induce inflammation and oxidative stress

[308]

 miR-30d-5p

SOCS1, SIRT1

NF-κB

Induce M1 macrophage polarization

[309]

 miR-221-5p

JNK2

NLRP3 inflammasome

Induce mitochondrial dysfunction and inflammation

[310]

 miR-199a-3p

PAK4

PAK4/Rab8a

Upregulate AM-mediated inflammation

[298]

Protective

 miR-146b-5p

TRAF6

NF-κB

Alleviate apoptosis

[311]

 miR-450b-5p

HMGB1

TLR4, RAGE

Alleviate apoptosis

[312]

 miR-95-5p

JAK2

JAK2/STAT3

Alleviate apoptosis

[313]

 miR-216a

JAK2

JAK2/STAT3, NF-κB

Alleviate inflammation

[314]

 miR-574-5p

HMGB1

NF-κB, NLRP3 inflammasome

Alleviate inflammation

[315]

 miR-155-5p

IL-17RB, IL-18R1, IL-22RA2

NF-κB

Alleviate inflammation

[316]

 miR-138-5p

NLRP3

NLRP3 inflammasome

Alleviate inflammation

[317]

 miR-182

GGPPS1

Alleviate inflammation

[318]

 miR-494-3p

CMPK2

NLRP3 inflammasome

Alleviate pyroptosis

[319]

 miR-150

MAPK

Alleviate inflammation, pulmonary edema and enhance epithelial integrity

[320]

 miR-27a

PTEN

AKT

Alleviate inflammation and promote cell proliferation

[321]

 miR-138-5p

EZH2

Inhibit M1 macrophage polarization

[322]

 miR-377-3p

mTOR

mTOR

Stimulate protective autophagy

[323]