Table 3 Biochemical data of the included studies in the systematic review

Akil et al. [40]

Baseline:134.8 ± 101.9 vs1067.9 ± 1276.9

–

Baseline: 1.4 ± 2.7 vs 16.8 ± 60.9

Baseline: 1.9 ± 0.7 vs 2.4 ± 1.1

72 h: 1.2 vs 1.7

Norepinephrine:

Baseline: 0.05 ± 0.04 0.2 ± 0.1

Akil et al. [39]

–

Baseline: 27.2 ± 2.9 vs 35 ± 5

12 h: 29 ± 3.3 vs 24 ± 3

24 h: 25.01 ± 2.8 vs 16 ± 3

48 h: 22.6 ± 3.1vs 12 ± 3

72 h: 20.02 ± 2.4 vs 10 ± 3

Baseline: 13.24 ± 9.7 vs 15.6 ± 5.4

12 h: 18.95 ± 16.32 vs 9.05 ± 3.9

24 h: 12.5 ± 10.5 vs 4.71 ± 2.3

48 h: 8.14 ± 5.9 vs 2.71 ± 1.5

72 h: 4.1 ± 3.4 vs 2.3 ± 1.2

Baseline: 2.7 ± 0.34 vs 4.1 ± 0.97

12 h: 1.7 ± 0.55 vs 2.1 ± 0.57

24 h: 1.57 ± 0.5 vs 1.6 ± 0.48

48 h: 1.7 ± 0.29 vs 1.3 ± 0.37

72 h: 2 ± 0.37 vs 1.1 ± 0.3

Norepinephrine:

Baseline: 0.603 ± 0.08 vs 0.83 ± 0.16

12 h: 0.6 ± 0.13 vs 0.19 ± 0.04

24 h: 0.47 ± 0.14 vs 0.045 ± 0.01

48 h:0.38 ± 0.11 vs 0.009 ± 0.005

Rieder et al. [41]

–

–

–

–

–

Supady et al. [35]

Baseline: 289.0(84.7–787.0) vs 357.0(177.4–1186.0)

72 h:112.0 (48.7–198.5) vs 98.6 (71–192.8)

Baseline:16.93 (12.86–34.22) vs 25.49 (14.8–37.44)

Baseline: 1.34 (0.37–5.98) vs 0.73 (0.50–1.84)

Baseline: 1.4 (0.9–1.8) vs 1.8(1.2–2.3)

72 h:1.25(0.93–1.85) vs 1.35(1.05–1.58)

Norepinephrine:

Baseline: 0.03(0.00–0.36) vs 0.15(0.04–0.22)

72 h: 0(0–0.1) vs 0.07(0.03–0.13)

Song et al. [43]

Baseline: 14.4 ± 18.91

72 h: 9.8 ± 9.0–

–

–

Geraci et al. [33 ]

Baseline: 22 (9–618)

72 h:11 (7–146)

Baseline: 117 (31–263)

72 h: 64 (7.8–105)

Baseline: 1.2 (0.21–3.8)

72 h: 0.19 (0.08–15)

Baseline: 1.60 (1.32–2.55)

72 h:1.35 (1.08–1.53)

–