Fig. 2

Secondary outcomes at day 28 according to the use of high-flow nasal cannula before mechanical ventilation. These Kaplan-Meier curves depict (A) intensive care unit (ICU) survival until day 28 as well as cumulative incidence of (B) ICU discharge, (C) successful ventilator weaning, (D) CRRT, (E) Prone position, and (F) Extracorporeal membrane oxygenation at day 28. MV; mechanical ventilation, HFNC-F; high-flow nasal cannula failure, ICU; intensive care unit, CRRT; continuous renal replacement therapy, ECMO; extracorporeal membrane oxygenation