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Fig. 1 | Respiratory Research

Fig. 1

From: The use of cultured human alveolar basal cells to mimic honeycomb formation in idiopathic pulmonary fibrosis

Fig. 1

Ectopic epithelial cells in peripheral IPF lung tissue. Representative images showing Hematoxylin and Eosin (H&E) stainings in control (n = 4) and IPF (n = 4) lung tissue (A). Representative IHC/IF images of control (n = 4) and IPF (n = 4) lung tissue incubated with antibodies detecting SP-C (B), MMP7, or basal (KRT5, KRT17, KRT14, p63)-, ciliated (AcTub)-, or secretory (SCGB1A1, MUC5AC, MUC5B) epithelial cell markers (C). White squares indicate regions imaged at higher magnification shown in the top right corner of the image (B, C). IHC/IF image quantifications of cells expressing specific markers within control (n = 4) and IPF (n = 4) tissue (D). Dots within the bar charts represent individual data points generated by analysis of six images of control (n = 4) and IPF (n = 4) lung tissue. Data are expressed as mean ± SEM (Mann–Whitney test, **** indicates p < 0.0001)

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Respiratory Research

ISSN: 1465-993X

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