Fig. 5
From: Unraveling EGFR-TKI resistance in lung cancer with high PD-L1 or TMB in EGFR-sensitive mutations
Pathway mutation differential and profile analysis in the high or low TMB value group. Differential analysis of signaling pathways: cell cycle (A), chromatin SWI/SNF complex (B), genome integrity (C), other (D), other signaling (E), PI3K signaling (F), and transcription factor (G); the mutation profile of signaling pathways in the group with EGFR E19del/L858R and high (H, TMB ≥ 4.4 muts/Mb) or low (I, TMB < 4.4 muts/Mb) TMB values. “ns”, “*”, “**”, “***” and “****” indicate P > 0.05, P < 0.05, P < 0.01, P < 0.001 and P < 0.0001, Wilcoxon test