Fig. 3
From: Unraveling EGFR-TKI resistance in lung cancer with high PD-L1 or TMB in EGFR-sensitive mutations
Mutation analysis in groups with high or low TMB values. (A) Overview of mutation profiles in patients with high tumor mutational burden (TMB-H, TMB ≥ 4.4 muts/Mb); (B) Overview of mutation profiles in patients with low tumor mutational burden (TMB-L, TMB < 4.4 muts/Mb); (C) Comutation analysis in patients with high tumor mutational burden; (D) Comutation analysis in patients with low tumor mutational burden; (E) Phylogenetic tree comparing mutations between patients with high and low tumor mutational burden; (F) Cobar plot of differentially mutated genes in patients with high and low tumor mutational burden. “**” and “***” indicate P < 0.01 and P < 0.001