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Table 3 Summary of DILD biomarker potentials of TRP metabolites in comparison with conventional serum biomarkers

From: Identification of kynurenine and quinolinic acid as promising serum biomarkers for drug-induced interstitial lung diseases

Comparisons

in ROC curve analyses

Diagnostic potentials (AUROC, 95% confidence interval)

TRP

KYN

QUNA

KYN/TRP

SP-D

KL-6

CRP

DAD/DAD-mixed vs. DILD recovery

0.80 (0.68–0.92)

0.94 (0.89–0.99)

0.89 (0.81–0.97)

0.97 (0.93–1.00)

0.88 (0.79–0.96)

0.66 (0.53–0.78)

0.88 (0.79–0.96)

DAD/DAD-mixed vs. DILD-tolerant

0.85 (0.73–0.97)

0.98 (0.94–1.00)

0.96 (0.90–1.00)

1.00 (0.98–1.00)

0.97 (0.93–1.00)

0.81 (0.67–0.94)

0.95 (0.88–1.00)

DAD/DAD-mixed vs. Lung cancer

0.82 (0.69–0.94)

0.96 (0.92–1.00)

0.94 (0.88–1.00)

0.98 (0.95–1.00)

0.94 (0.88–0.99)

0.84 (0.74–0.93)

0.93 (0.85–1.00)

DAD/DAD-mixed vs. BP

0.78 (0.62–0.93)

0.94 (0.87–1.00)

0.92 (0.82–1.00)

0.95 (0.88–1.00)

0.94 (0.86–1.00)

0.95 (0.87–1.00)

0.63 (0.40–0.85)

DAD/DAD-mixed vs. NTM

0.85 (0.73–0.98)

0.96 (0.89–1.00)

0.90 (0.79–1.00)

0.98 (0.93–1.00)

0.84 (0.70–0.98)

0.88 (0.76–1.00)

0.88 (0.75–1.00)

DAD/DAD-mixed vs. IIPs

0.77 (0.63–0.91)

0.87 (0.77–0.98)

0.87 (0.76–0.99)

0.90 (0.80–0.99)

0.59 (0.42–0.76)

0.63 (0.46–0.79)

0.88 (0.77–0.98)

DAD/DAD-mixed vs. CTD

0.80 (0.66–0.93)

0.88 (0.77–0.99)

0.91 (0.82–1.00)

0.93 (0.86–1.00)

0.69 (0.52–0.86)

0.53 (0.35–0.72)

0.83 (0.69–0.97)

DAD/DAD-mixed vs. COPD

0.80 (0.66–0.95)

0.91 (0.81–1.00)

0.91 (0.82–1.00)

0.94 (0.87–1.00)

0.92 (0.84–1.00)

0.78 (0.61–0.96)

0.93 (0.86–1.00)

DAD/DAD-mixed vs. BA

0.89 (0.79–1.00)

0.99 (0.95–1.00)

0.98 (0.94–1.00)

1.00 (0.98–1.00)

0.99 (0.97–1.00)

0.96 (0.91–1.00)

0.98 (0.94–1.00)

DAD/DAD-mixed vs. HC

0.85 (0.72–0.98)

1.00 (1.00–1.00)

1.00 (0.99–1.00)

1.00 (1.00–1.00)

N.A

N.A

N.A

All-DILD vs. DILD recovery

0.68 (0.59–0.78)

0.82 (0.75–0.89)

0.81 (0.74–0.89)

0.86 (0.80–0.92)

0.77 (0.69–0.85)

0.59 (0.49–0.69)

0.75 (0.65–0.84)

All-DILD vs. DIKLD-tolerant

0.75 (0.64–0.86)

0.85 (0.77–0.93)

0.90 (0.83–0.97)

0.91 (0.85–0.97)

0.89 (0.83–0.96)

0.74 (0.62–0.86)

0.88 (0.79–0.97)

All-DILD vs. Lung cancer

0.69 (0.60–0.78)

0.83 (0.76–0.90)

0.86 (0.80–0.93)

0.86 (0.80–0.93)

0.85 (0.78–0.92)

0.76 (0.67–0.84)

0.78 (0.69–0.86)

All-DILD vs. BP

0.59 (0.47–0.72)

0.79 (0.67–0.90)

0.80 (0.69–0.91)

0.79 (0.68–0.90)

0.86 (0.76–0.95)

0.88 (0.79–0.96)

0.58 (0.40–0.76)

All-DILD vs. NTM

0.74 (0.63–0.85)

0.83 (0.73–0.93)

0.79 (0.67–0.90)

0.88 (0.80–0.96)

0.73 (0.60–0.87)

0.80 (0.68–0.91)

0.76 (0.61–0.91)

All-DILD vs. IIPs

0.65 (0.53–0.77)

0.73 (0.62–0.84)

0.77 (0.65–0.89)

0.77 (0.66–0.88)

0.64 (0.50–0.78)

0.65 (0.52–0.77)

0.68 (0.56–0.80)

All-DILD vs. CTD

0.66 (0.54–0.78)

0.75 (0.63–0.87)

0.80 (0.70–0.89)

0.80 (0.69–0.90)

0.62 (0.47–0.78)

0.56 (0.41–0.71)

0.73 (0.58–0.89)

All-DILD vs. COPD

0.68 (0.55–0.81)

0.79 (0.66–0.91)

0.80 (0.69–0.91)

0.82 (0.70–0.94)

0.81 (0.70–0.92)

0.72 (0.56–0.88)

0.76 (0.64–0.88)

All-DILD vs. BA

0.82 (0.71–0.93)

0.85 (0.77–0.93)

0.93 (0.87–0.98)

0.91 (0.85–0.97)

0.94 (0.89–0.99)

0.89 (0.81–0.96)

0.92 (0.86–0.98)

All-DILD vs. HC

0.73 (0.63–0.82)

0.97 (0.94–1.00)

0.98 (0.95–1.00)

0.98 (0.95–1.00)

N.A

N.A

N.A

  1. AUROC values were calculated from ROC curves, and those with statistical significance (p-value < 0.05) are indicated in bold letters
  2. DILD recovery: patients recovered from DILD; DILD-tolerant: the patient group taking similar medications to the DILD group but without DILD onset; BP: bacterial pneumonia; NTM: nontuberculous mycobacteriosis; IIPs: idiopathic interstitial pneumonias; CTD: lung disease associated with connective tissue disease; COPD: chronic obstructive pulmonary disease; BA: bronchial asthma; HC: healthy control; N.A.: not applicable
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Respiratory Research

ISSN: 1465-993X

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