Table 2 Statistical comparison of serum concentrations of TRP metabolites and TRP/KYN ratio among patient groups
Groups | TRP# (µM) | KYN# (µM) | QUNA (nM) | KYN/TRP#(ratio) | ||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
Median Conc | Adjusted p-value | Median Conc | Adjusted p-value | Median Conc | Adjusted p-value | Median Conc | Adjusted p-value | |||||
(range) | vs DAD/DAD mixed | vs All-DILD | (range) | vs DAD/DAD mixed | vs All-DILD | (range) | vs DAD/DAD mixed | vs All-DILD | (range) | vs DAD/DAD mixed | vs All-DILD | |
All-DILD | 41.3 (30.4–54.0) | – | – | 4.0 (2.8–5.4) | – | – | 1193.5 (593.6–1910.9) | – | – | 0.108 (0.066–0.155) | – | – |
DAD/DAD-mixed | 32.3 (22.4–40.7) | – | – | 5.0 (4.3–5.5) | – | – | 1557.9 (955.4–2563.6) | – | – | 0.158 (0.111–0.211) | – | – |
OP | 44.3 (39.2–54.2) | N.S | – | 3.4 (2.6–4.6) | 0.03 | – | 821.0 (537.3–1512.6) | 0.02 | – | 0.085 (0.057–0.131) | < 0.01 | – |
NSIP | 41.5 (28.9–59.3) | N.S | – | 3.5 (2.5–5.3) | N.S | – | 1246.1 (550.2–1609.7) | N.S | – | 0.097 (0.063–0.149) | N.S | – |
Other | 36.1 | – | – | 2.8 | – | – | 1165.8 | – | – | 0.079 | – | – |
DILD recovery | 52.1 (45.7–60.1) | < 0.01 | < 0.01 | 2.1 (1.6–2.9) | < 0.01 | < 0.01 | 325.9 (190.0–580.6) | < 0.01 | < 0.01 | 0.038 (0.029–0.058) | < 0.01 | < 0.01 |
DILD-tolerant | 55.3 (50.3–62.6) | < 0.01 | < 0.01 | 2.1 (1.7–2.6) | < 0.01 | < 0.01 | 286.9 (206.7–403.4) | < 0.01 | < 0.01 | 0.036 (0.030–0.052) | < 0.01 | < 0.01 |
Lung cancer | 50.4 (44.3–57.8) | < 0.01 | < 0.01 | 2.1 (1.7–3.0) | < 0.01 | < 0.01 | 252.3 (191.0–474.1) | < 0.01 | < 0.01 | 0.040 (0.032–0.060) | < 0.01 | < 0.01 |
BP | 45.8 (41.9–52.1) | N.S | N.S | 2.3 (1.8–3.2) | < 0.01 | < 0.01 | 486.8 (341.6–606.1) | < 0.01 | < 0.01 | 0.046 (0.038–0.076) | < 0.01 | < 0.01 |
NTM | 54.0 (47.1–61.2) | 0.02 | 0.03 | 2.2 (1.9–2.6) | < 0.01 | < 0.01 | 472.2 (283.4–563.9) | < 0.01 | < 0.01 | 0.039 (0.032–0.048) | < 0.01 | < 0.01 |
IIPs | 47.9 (41.7–60.7) | 0.02 | N.S | 2.4 (1.9–3.5) | < 0.01 | < 0.01 | 496.0 (241.7–620.3) | < 0.01 | < 0.01 | 0.050 (0.036–0.067) | < 0.01 | < 0.01 |
CTD | 49.3 (41.5–59.3) | 0.01 | N.S | 2.4 (1.6–3.2) | < 0.01 | 0.04 | 480.9 (289.2–663.4) | < 0.01 | < 0.01 | 0.051 (0.030–0.094) | < 0.01 | < 0.01 |
COPD | 51.6 (46.6–57.1) | 0.02 | N.S | 2.2 (1.6–3.4) | < 0.01 | 0.03 | 365.8 (266.9–615.8) | < 0.01 | < 0.01 | 0.047 (0.027–0.079) | < 0.01 | < 0.01 |
BA | 61.0 (53.8–64.5) |  < 0.01 | < 0.01 | 2.1 (2.0–2.6) | < 0.01 | < 0.01 | 263.5 (226.0–377.4) | < 0.01 | < 0.01 | 0.039 (0.031–0.044) | < 0.01 | < 0.01 |
HC | 51.4 (47.0–57.4) |  < 0.01 | < 0.01 | 1.4 (1.2–1.6) | < 0.01 | < 0.01 | 210 (174.8–245.4) | < 0.01 | < 0.01 | 0.028 (0.025–0.030) | < 0.01 | < 0.01 |