Fig. 1

The effect of anti-CD147 in OVA-induced airway inflammation and histological changes of asthmatic mice

Asthmatic mouse model was established with OVA, and treated with anti-CD147 or Isotype antibody. Mice sensitized and challenged with PBS were used as the control. The number of (A) total cells and (B) eosinophils in BALF of mice in each group were counted under a microscope (n = 6). (C) The levels of IL-4, IL-13, and IL-5 in BALF were assayed by ELISA (n = 6). (D) Representative photographs of lung sections were stained with HE, the nuclei appear blue, the cytoplasm appears pink. Magnification ×400, scale bar = 50 μm. (E) Quantification of airway wall thickness of mice in each group (n = 6). Data were presented as mean ± SD, and analyzed by one-way ANOVA with Bonferroni correction. *P < 0.05, vs. control; ^#P < 0.05, vs. OVA