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Table 4 The diagnostic performances of selected features for tuberculous pleurisy and hematologic malignant pleural effusion in pleural effusions with ADA ≥ 40 IU/L

From: Features which discriminate between tuberculosis and haematologic malignancy as the cause of pleural effusions with high adenosine deaminase

Categories

Sensitivity (CI 95%)

Specificity (CI 95%)

NPV (CI 95%)

PPV (CI 95%)

Accuracy (CI 95%)

Tuberculous pleurisy

  Lymphocyte ≥ 50%

0.755 (0.708–0.797)

0.887 (0.862–0.908)

0.880 (0.855–0.902)

0.767 (0.720–0.809)

0.843 (0.821–0.864)

  Lymphocyte ≥ 35%

0.885 (0.849–0.916)

0.823 (0.794–0.850)

0.936 (0.914–0.953)

0.712 (0.669–0.753)

0.843 (0.821–0.865)

  LD/ADA < 18

0.917 (0.885–0.943)

0.801 (0.771–0.829)

0.951 (0.932–0.967)

0.695 (0.652–0.735)

0.840 (0.817–0.860)

  Lymphocyte ≥ 35%

  and LD/ADA < 18

0.837 (0.796–0.873)

0.926 (0.905–0.944)

0.920 (0.899–0.938)

0.849 (0.808–0.884)

0.897 (0.878–0.914)

  Lymphocyte ≥ 35%

  and LD/ADA < 18

  and ADA < 150

0.824 (0.782–0.861)

0.937 (0.917–0.953)

0.915 (0.893–0.934)

0.866 (0.826–0.899)

0.900 (0.880–0.916)

Hematologic MPE in pleural effusion with ADA ≥ 150

  PMN < 50%

0.913 (0.720–0.989)

0.850 (0.765–0.914)

0.977 (0.919–0.997)

0.583 (0.408–0.745)

0.862 (0.788–0.917)

  PMN < 50%

  and serum LD ≥ 2× serum ULN

0.870 (0.664–0.972)

0.857 (0.753–0.929)

0.952 (0.867–0.990)

0.667 (0.472–0.827)

0.860 (0.822–0.941)

  1. Continuous variables were converted to categorical variables using the highest Youden’s index or clinically meaningful cut-off values in logistic regression analysis to facilitate clinical interpretation
  2. ADA = adenosine deaminase, CI = confidence interval, LD = lactate dehydrogenase, MPE = malignant pleural effusion, NPV = negative predictive value, PMN = polymorphonuclear neutrophil, PPV = positive predictive value, ULN = upper limit of normal