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Fig. 6 | Respiratory Research

Fig. 6

From: Biochemical and transcriptomic evaluation of a 3D lung organoid platform for pre-clinical testing of active substances targeting senescence

Fig. 6

Doxorubicin induces the expression of detoxification factors in goblet cells. Organoids were pre-treated with Dox or control medium for 48 h. The organoids pre-incubated with control medium were treated with control medium or Quer, the organoids pre-incubated with Dox were treated with Dox or the combination of Quer and Dox for additional 48 h. (A) Proportion of the goblet cell cluster among all clusters. Data were compared by a Bayesian model. (B) Dot plot showing expression of goblet markers and factors associated with detoxification. (C) UMAP visualization of factors associated with detoxification

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Respiratory Research

ISSN: 1465-993X

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