Fig. 7
From: Tuftelin1 drives experimental pulmonary fibrosis progression by facilitating stress fiber assembly
Schematic diagram shows TUFT1 Involvement in the Pathophysiological Processes of Pulmonary Fibrosis. Our study has unveiled a schematic model elucidating the role of TUFT1 in the pathophysiological processes underlying pulmonary fibrosis. Specifically, our data demonstrate that TUFT1 orchestrates the translocation of pY256N-WASP into the cell nucleus, which facilitates the assembly of actin filaments, culminating in the enhanced formation of stress fibers. This heightened TUFT1-induced stress fiber formation appears to drive the cellular phenotypic transition toward a pro-fibrotic state