Table 4 Risk factors of MACCE stratified by level of homocysteine
Variables | Univariable | Multivariable | ||
|---|---|---|---|---|
HR (95% CI) | P | HR (95% CI) | P | |
Patients with Homocysteine ≤ 15 μmol/L |  |  |  |  |
 OSA | 1.41 (1.07–1.87) | 0.015 | 1.36 (1.02–1.83) | 0.039 |
 Age | 1.01 (1.00–1.03) | 0.098 | 1.01 (0.99–1.02) | 0.402 |
 Female | 0.99 (0.71–1.38) | 0.958 | 0.89 (0.60–1.32) | 0.563 |
 BMI | 1.01 (0.98–1.05) | 0.503 | 1.00 (0.96–1.04) | 0.941 |
 Hypertension | 1.34 (0.99–1.81) | 0.057 | 1.22 (0.89–1.67) | 0.219 |
 Diabetes mellitus | 1.36 (1.03–1.80) | 0.029 | 1.33 (1.00–1.77) | 0.048 |
 Hyperlipidemia | 0.94 (0.69–1.27) | 0.671 | 0.96 (0.70–1.32) | 0.794 |
 Prior MI | 1.01 (0.70–1.47) | 0.956 | 0.98 (0.67–1.44) | 0.925 |
 Prior stroke | 1.75 (1.15–2.66) | 0.009 | 1.50 (0.97–2.31) | 0.067 |
 STEMI | 1.15 (0.84–1.58) | 0.391 | 1.22 (0.88–1.69) | 0.242 |
 Current smoking | 0.96 (0.73–1.27) | 0.798 | 1.05 (0.76–1.44) | 0.774 |
 Drinking | 0.88 (0.65–1.18) | 0.387 | 0.88 (0.64–1.21) | 0.432 |
 eGFR < 90 mL/min/1.73 m2 | 1.39 (1.00–1.93) | 0.049 | 1.25 (0.88–1.76) | 0.206 |
Patients with homocysteine > 15 μmol/L |  |  |  |  |
 OSA | 1.01 (0.70–1.46) | 0.961 | 0.92 (0.62–1.36) | 0.668 |
 Age | 1.02 (1.01–1.04) | 0.010 | 1.02 (1.00–1.04) | 0.131 |
 Female | 1.96 (1.15–3.32) | 0.013 | 1.46 (0.78–2.75) | 0.237 |
 BMI | 1.02 (0.97–1.07) | 0.436 | 1.04 (0.98–1.09) | 0.206 |
 Hypertension | 1.37 (0.92–2.06) | 0.121 | 1.18 (0.77–1.80) | 0.448 |
 Diabetes mellitus | 1.44 (0.95–2.17) | 0.086 | 1.16 (0.75–1.80) | 0.500 |
 Hyperlipidemia | 1.24 (0.82–1.86) | 0.313 | 1.11 (0.73–1.69) | 0.632 |
 Prior MI | 1.50 (0.97–2.33) | 0.071 | 1.45 (0.92–2.27) | 0.106 |
 Prior stroke | 1.90 (1.19–3.03) | 0.007 | 1.60 (0.98–2.62) | 0.060 |
 STEMI | 1.17 (0.78–1.75) | 0.440 | 1.43 (0.93–2.18) | 0.102 |
 Current smoking | 0.72 (0.50–1.04) | 0.082 | 0.85 (0.56–1.29) | 0.441 |
 Drinking | 1.00 (0.68–1.45) | 0.986 | 1.21 (0.81–1.83) | 0.354 |
 eGFR < 90 mL/min/1.73 m2 | 1.35 (0.93–1.97) | 0.112 | 1.09 (0.72–1.64) | 0.686 |