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Table 1 Baseline characteristics of patients according to status on day 21 of ARDSNet and CARDS cohort

From: A combination of mild-moderate hypoxemia and low compliance is highly prevalent in persistent ARDS: a retrospective study

 

ARDSNet cohort

CARDS cohort

 

Ventilated in Control modes1 (n = 124)

Ventilated in Assisted modes1 (n = 302)

Extubated

(n = 1937)

Deceased

(n = 546)

Ventilated in Control modes1 (n = 96)

Ventilated in

Assisted modes1 (n = 51)

Extubated

(n = 58)

Deceased

(n = 144)

Age

52.5

(41.0–65.8)

54.0

(42.0–65.0)

50.0

(39.0–60.0)*

58.0

(45.0–71.0)*

71.0

(61.0–75.8)

69.0

(61.0–74.0)

63.5

(53.0–75.0)**

72.0

(64.0–77.0)

Female sex

n (%)

50

(40.3)

138

(45.7)

975

(50.3)

246

(45.1)

32

(33.3)

20

(39.2)

23

(39.7)

45

(31.5)

Baseline SOFA score

7

(5–9)

7

(5–9)

6

(4–8)#

8

(6–10)#

4

(4–6)

4

(4–8)

4

(4–6)##

5

(4–7)##

Non-respiratory SOFA

3

(1–6)

4

(2–6)$

3

(1–5)

5

(3–7)$

1

(0–3)

1

(0–4)

1

(0–2)

1

(0–3)

PaO2:FiO2 at baseline

103

(81–147)˚

146

(107–195)

150

(106–200)

127

(89–177)˚

120

(88–153)

131

(110–181)

118

(101–158)

101

(76–147)˚˚

Crs at baseline

27

(22–35)

28

(21–36)

30

(23–40)¨

28

(21–38)

36

(30–45)

40

(35–48)

38

(33–45)

32

(26–39)¨¨

MH-LoC at baseline2

13/108

(12.0)•

56/223

(25.1)

357/1527

(23.4)

76/405

(18.8)

2/94

(2.1)

0/43

(0.0)

2/55

(3.6)

6/128

(4.7)

  1. Abbreviations: ARDS, acute respiratory distress syndrome; CARDS, COVID-19-related acute respiratory distress syndrome; n, number; SOFA, sequential organ failure assessment; PaO2:FiO2, partial pressure of arterial oxygen to fraction of inspired oxygen ratio; Crs, compliance; MH-LoC, mild-moderate hypoxemia and low compliance
  2. Age, baseline SOFA, non-respiratory SOFA and lung mechanics at baseline are presented as median with interquartile range (IQR) and compared using the Kruskal-Wallis test. Sex is presented as percentage and compared using the chi-squared test. Pairwise comparisons were corrected using the Bonferroni method, and statistical significance was considered at an α level of 0.05
  3. 1The “ventilated in control modes” group consisted of patients who were on mechanical ventilation and had available data on oxygenation and compliance on day 21; the “ventilated in assisted modes” group consisted of patients who remained on mechanical ventilation but did not have data on compliance, mostly because they were ventilated on assisted or partially assisted modes by day 21; the “extubated” group consisted of patients who were liberated from mechanical ventilation by day 21; and the “deceased” group consisted of patients who died by day 21
  4. 2Due to missing data on respiratory system compliance at baseline, the total number of patients is less for this variable (shown as denominator)
  5. *Deceased vs. all other groups p < 0.05, and extubated vs. ventilated in assisted modes p < 0.001; # Deceased vs. all other groups, and extubated vs. ventilated in control, assisted modes p < 0.05; $ Deceased vs. extubated, ventilated in control modes, and ventilated in assisted modes vs. extubated p < 0.001; ˚ Deceased vs. all other groups p < 0.05, and ventilated in control modes vs. ventilated in assisted modes, extubated p < 0.001; ¨ Extubated vs. deceased, ventilated in assisted modes p < 0.05; •Ventilated in control modes vs. ventilated in assisted modes, extubated p < 0.05
  6. **Extubated vs. ventilated in control modes, deceased p < 0.05; ##Deceased vs. extubated p < 0.05; ˚˚Deceased vs. ventilated in assisted modes p < 0.01; ¨¨ Deceased vs. all other groups p < 0.01
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Respiratory Research

ISSN: 1465-993X

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