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Table 2 Top proteins with significant differences in ILD pathologies

From: Bronchoalveolar cytokine profile differentiates Pulmonary Langerhans cell histiocytosis patients from other smoking-related interstitial lung diseases

Protein

PLCH vs SR-ILD

PLCH vs IPF

FC

p value

FC

p value

Group I

 GRO (CXCL1)

1.822

0.010

1.934

0.006

 TARC (CCL17)

3.861

 < 0.0001

1.633

0.001

 Leptin

3.103

 < 0.0001

1.496

0.006

 IGFBP-3

4.899

0.001

3.799

0.012

 TGF-β2

2.266

 < 0.0001

1.511

0.006

 TIMP-2

7.029

0.004

3.072

0.028

Group II

 BDNF

1.897

0.017

0.598

0.002

 Fractalkine (CX3CL1)

2.367

0.014

0.483

0.003

 GDNF

2.586

0.007

0.586

0.028

 MCP-4

2.676

0.033

0.373

0.001

Group III

 MCSF

2.955

0.003

0.643

ns

 MIP-1δ

4.765

0.020

1.431

ns

 TGF-β1

2.131

0.017

0.771

ns

 TNF-α

2.633

0.005

0.644

ns

 TNF-ĂŸ

2.628

0.019

0.831

ns

 Oncostatin M (OSM)

3.623

0.009

1.120

ns

 PDGF-BB

2.179

0.002

0.875

ns

 BLC

2.977

0.044

0.611

ns

 Ck β 8–1

2.794

0.023

0.696

ns

 FGF-6

3.174

0.004

1.463

ns

 GCP-2

3.720

0.016

0.701

ns

 IL-16

3.462

0.003

0.954

ns

 IP-10

3.561

0.000

1.205

ns

Group IV

 IL-1β

1.110

ns

0.574

0.009

 IL-8 (CXCL8)

0.589

ns

0.133

 < 0.0001

 IL-15

1.455

ns

0.617

0.007

 IFN-γ

1.466

ns

0.646

0.043

 MCP-1 (CCL2)

1.393

ns

0.477

 < 0.0001

 MIG (CXCL9)

0.484

ns

0.158

0.010

 FGF-9

1.714

ns

0.508

0.003

 IGFBP-2

0.419

ns

0.159

0.009

 TGF-β3

1.853

ns

0.265

0.005

  1. Differential protein expression (Fold change) between groups (p-Value < 0.05) is shown
  2. Statistical significance was determined by two-way analysis of variance (ANOVA)/Tukey’s multiple comparison test
  3. FC, Fold Change; ILD, Interstitial lung disease; PLCH, Pulmonary Langerhans cell histiocytosis; SR-ILD, smoking related interstitial lung disease; IPF, idiopathic pulmonary fibrosis; ns, not significant
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Respiratory Research

ISSN: 1465-993X

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