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Table 1  Demographic and clinical characteristics of ILD patients

From: Bronchoalveolar cytokine profile differentiates Pulmonary Langerhans cell histiocytosis patients from other smoking-related interstitial lung diseases

 

PLCH

SR-ILD

IPF

Number of patients

7

16

13

Predominant HRCT pattern (n, %)

 Nodules or micronodules

3 (42.8%)

–

–

 Nodules and cysts

2 (28.6%)

–

–

 Cysts

2 (28.6%)

–

–

Gender

 Male/female (n, %)

2/5 (29–71%)

12/4 (75–25%)

12/1 (92–8%)a

Age (yr)

46 (42–48)

66 (52–72)a

72 (67–77)a

Smoking status (n, %)

 Non-smokers

0 (0%)

0 (0%)

2 (15%)

 Former smokers

1 (14%)

6 (40%)

2 (15%)

 Current smokers

6 (86%)

10 (60%)

9 (69%)

Cigarettes (pack/yr)

25 (14–40)

47 (28–78)

35 (30–44)

Pulmonary function test

 FVC % predicted

89.71 (14.77)

93.81 (15.73)

80.00 (9.6)b

 FEV1% predicted

71.71 (19.11)

82.56 (18.71)

82.85 (11.64)

 FEV1/FVC, %

63.14 (12.23)

66.80 (11.28)

75.86 (8.67)b

 DLCO, %

64.14 (15.32)

67.07 (19.21)

51.23 (18.42)b

BAL cell counts (%)

 Macrophages

70 (21.6)

71 (17.4)

59.75 (20.66)

 PML

14.5 (12.67)

15.18 (10.09)

19.75 (18.86)

 Lymphocytes

13 (9.84)

9.56 (7.49)

10.91 (5.4)

  1. Values in bold indicate statistically significant results
  2. Data are presented as %, median (interquartile range) or mean (SD) as appropriated
  3. The p-values for differences between groups are indicated as a and b
  4. FVC, forced vital capacity; FEV1, forced expiratory volume in 1 s; DLCO, diffuse capacity of the lung for carbon monoxide; BAL, bronchoalveolar lavage; PML, polymorphonuclear leukocytes; ILD, Interstitial lung disease; PLCH, Pulmonary Langerhans cell histiocytosis; SR-ILD, smoking related interstitial lung disease; IPF idiopathic pulmonary fibrosis
  5. aP < 0.05 compared to PLCH
  6. bP < 0.05 compared to SR-ILD