Table 1 Pleiotropic genes as targets for approved or investigational drugs
Trait pair | Lead SNP | PPLACO | Nearest Gene | Drug | Indication | Action* |
|---|---|---|---|---|---|---|
FEV1-PUD | rs13430465 | 1.33 × 10− 8 | RDH14 | Vitamin A | Vitamin A deficiency | Substrate |
FEV1-GORD | rs1431721 | 2.30 × 10− 8 | CHRM3 | Oxyphencyclimine | Peptic ulcer disease | Antagonist |
FEV1-IBD | rs1008833 | 3.26 × 10− 9 | PIK3C2B | Fostamatinib | Chronic immune thrombocytopenia | Inhibitor |
FEV1-IBD | rs9270979 | 5.29 × 10− 24 | HLA-DRB1 | Glatiramer | Multiple sclerosis | Binder |
FEV1-IBS | rs4367292 | 1.23 × 10− 8 | HSPA4 | Phenethyl isothiocyanate | Leukemia, lung cancer (in trials) | Unknown |
FVC-PUD | rs13430465 | 9.67 × 10− 9 | RDH14 | Vitamin A | Vitamin A deficiency | Substrate |
FVC-GORD | rs13425141 | 7.06 × 10− 9 | MAP2 | Estramustine | Prostate cancer | Antagonist |
FVC-GORD | rs7613360 | 5.23 × 10− 10 | MST1R | Crizotinib | Non-small cell lung cancer | Inhibitor |
FVC-IBD | rs1008833 | 4.91 × 10− 8 | PIK3C2B | Fostamatinib | Chronic immune thrombocytopenia | Inhibitor |
FVC-IBD | rs4705885 | 7.98 × 10− 11 | HINT1 | Sofosbuvir | Hepatitis C virus infections | Substrate |
FVC-IBD | rs9270911 | 1.16 × 10− 23 | HLA-DRB1 | Glatiramer | Multiple sclerosis | Binder |
FVC-IBS | rs9268846 | 2.16 × 10− 9 | HLA-DRA | 1D09C3 | Cancer (in trials) | Unknown |
FVC-IBS | rs3017666 | 2.28 × 10− 11 | GANAB | Miglitol | Non-insulin-dependent diabetes mellitus | Antagonist |
FEV1/FVC-PUD | rs1264318 | 1.13 × 10− 9 | DDR1 | Pralsetinib | Non-small cell lung cancer | Inhibitor |
FEV1/FVC-GORD | rs11720018 | 9.10 × 10− 10 | CACNA1D | Trimebutine | Irritable bowel syndrome | Inhibitor |
FEV1/FVC-GORD | rs4790311 | 1.10 × 10− 8 | SMG6 | Grn163l | Leukemia and solid tumors | Unknown |
FEV1/FVC-IBD | rs9270911 | 3.28 × 10− 20 | HLA-DRB1 | Glatiramer | Multiple sclerosis | Binder |
FEV1/FVC-IBD | rs4944210 | 4.76 × 10− 8 | NARS2 | Asparagine | Nutritional supplementation | Unknown |
FEV1/FVC-IBD | rs12720356 | 1.38 × 10− 8 | TYK2 | Tofacitinib | Ulcerative colitis | Inhibitor |
FEV1/FVC-IBS | rs4367292 | 2.50 × 10− 8 | HSPA4 | Phenethyl isothiocyanate | Leukemia, lung cancer (in trials) | Unknown |
FEV1/FVC-IBS | rs9260603 | 3.05 × 10− 13 | HLA-A | Nelipepimut-S | Prostate and breast cancer. | Unknown |
FEV1/FVC-IBS | rs8070954 | 3.63 × 10− 8 | SMG6 | Grn163l | Leukemia and solid tumors | Unknown |