Fig. 3
From: An epithelial gene signature of trans-IL-6 signaling defines a subgroup of type 2-low asthma
Generation of the IL-6 + sIL-6Rα Gene signature. The IL-6 + IL-6Rα Gene signature generation was generated from the significantly regulated genes in human airway epithelial cells by IL-6 + sIL-6Rα stimulation after passage through 3 filters. The core enrichment genes generated by GSEA [24], are genes that contribute to the leading-edge subset within the gene set. This is the subset of genes that contributes most to the enrichment result. B, The effect of Olamkicept and Tocilizumab on the IL-6 + sIL-6Rα gene signature expression in the presence of IL-6 + sIL-6Rα stimulation. DEG; differentially expressed genes, Th2; T helper type-2