Skip to main content

Table 3 Characteristics of test participants stratified by PRMfSAD

From: Deep learning parametric response mapping from inspiratory chest CT scans: a new approach for small airway disease screening

 

GT PRMfSAD > 15%

GT PRMfSAD ≤ 15%

p-value

Pred PRMfSAD > 22.8%

Pred PRMfSAD ≤ 22.8%

p-value

No. of subjects

46

30

…

45

31

…

Sex, Female, No. (%)

16 (34.8)

13 (43.3)

0.453

14 (31.1)

15 (48.4)

0.128

Age, y

63.8 ± 11.5

58.9 ± 9.3

0.056

62.5 ± 11.7

60.9 ± 9.7

0.55

BMI, kg/m2

22.7 ± 2.8

24.7 ± 3.3

0.007

22.4 ± 2.6

25.1 ± 3.2

 < 0.001

Chronic cough or phlegm, No. (%)

5 (10.9)

3 (10)

0.904

4 (8.9)

4 (12.9)

0.709

FEV1 (%)

98.1 ± 8

101.3 ± 12.4

0.176

99.3 ± 8.3

99.3 ± 12.2

0.999

FEV1/FVC (%)

88.6 ± 6.6

87.4 ± 8.3

0.483

89.8 ± 5.9

85.7 ± 8.5

0.023

Pred PRMfSAD

28.2 ± 6.7

19.2 ± 6.2

 < 0.001

…

…

…

Inflammatory SAD, No. (%)

25 (54.3)

4 (13.3)

 < 0.001

22 (48.9)

7 (22.6)

0.02

Bronchial wall thickening, No. (%)

2 (4.3)

2 (4.3)

0.645

4 (8.9)

0 (0)

0.141

Bronchial dilation, No. (%)

17 (37)

7 (23.3)

0.212

18 (40)

6 (19.4)

0.057

CLE score

1.2 ± 1

0.7 ± 1

0.045

1.2 ± 1

0.8 ± 1

0.13

Paraseptal emphysema, No. (%)

16 (34.8)

5 (16.7)

0.084

13 (28.9)

8 (25.8)

0.768

Panlobular emphysema, No. (%)

2 (4.3)

1 (3.3)

0.658

2 (4.4)

1 (3.2)

0.789

Tracheal coronal diameter (cm)

1.7 ± 0.2

1.6 ± 0.2

0.022

1.7 ± 0.2

1.6 ± 0.2

0.012

Tracheal sagittal diameter (cm)

1.9 ± 0.3

1.7 ± 0.3

0.031

1.9 ± 0.3

1.7 ± 0.3

0.019

Pulmonary artery diameter (cm)

2.6 ± 0.3

2.6 ± 0.3

0.42

2.5 ± 0.3

2.7 ± 0.3

0.046

Aortic diameter (cm)

3.3 ± 0.4

3.4 ± 0.5

0.932

3.3 ± 0.4

3.4 ± 0.5

0.165

SSIM

0.87 ± 0.04

0.86 ± 0.03

0.248

0.86 ± 0.04

0.87 ± 0.03

0.154

  1. Data are mean ± SD unless indicated otherwise
  2. BMI: body mass index; FEV1: forced expiratory volume in the first second; FVC: forced vital capacity; PRM: parametric response mapping; fSAD: functional small airway disease; PRMfSAD: the volume percentage of fSAD in PRM; GT: ground truth; CLE: centrilobular emphysema; SSIM: structural similarity index