Table 1 Expression signal (log2) and fold change of selected pro-inflammatory cytokines. * marks significant differences of ‘old’ compared to ‘young’ in the same condition (p < 0.05), based on the p-value analyzed using the Transcriptome Analysis Console Software (TAC 4.0, Thermo Fisher Scientific)
From: Age-dependent inflammatory response is altered in an ex vivo model of bacterial pneumonia
Gene | Ctrl young | Ctrl old | fold change | p-value | PAO1 young | PAO1 old | fold change | p-value | D61 young | D61 old | fold change | p-value |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
Tnf | 8.71 | 9.99 | 2.4 | 0.0512 | 12.01 | 13.84 | 3.6 | 0.0342* | 13.96 | 15.13 | 2.3 | 0.1439 |
Il1b | 13.39 | 15.19 | 3.5 | 0.0181* | 15.84 | 17.47 | 3.1 | 0.0430* | 16.66 | 18.10 | 2.7 | 0.1129 |
Il6 | 13.66 | 14.72 | 2.1 | 0.0391* | 15.92 | 16.38 | 1.4 | 0.1036 | 16.96 | 17.65 | 1.6 | 0.2281 |
Ccl3 | 14.41 | 15.54 | 2.2 | 0.0922 | 17.27 | 18.48 | 2.3 | 0.2546 | 18.56 | 19.23 | 1.6 | 0.5090 |
Ccl20 | 9.00 | 6.61 | -5.3 | 0.8400 | 12.44 | 14.05 | 3.0 | 0.6498 | 13.70 | 13.78 | 1.1 | 0.7384 |
Cxcl1 | 15.23 | 16.27 | 2.1 | 0.0046* | 18.23 | 18.60 | 1.3 | 0.4739 | 18.55 | 18.43 | -1.1 | 0.8377 |
Il17a | 6.30 | 6.22 | -1.1 | 0.7365 | 6.54 | 7.88 | 2.5 | 0.0127* | 6.89 | 8.23 | 2.5 | < 0.001* |