Fig. 7
From: Age-dependent inflammatory response is altered in an ex vivo model of bacterial pneumonia
Inflamm-aging modulates the immune response towards P. aeruginosa infection in PCLS and neutrophils. In summary, cytokine responses were found to be increased in PCLS from old compared to young mice upon infection with P. aeruginosa PAO1 or a clinical isolate D61. On isolated neutrophils, receptor expression upon bacterial infection was age-dependently reduced. Both findings highlight the changes of the immune system with aging that are crucial for pulmonary infections